Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 370767..371283 Replicon chromosome
Accession NZ_CP070564
Organism Klebsiella pneumoniae strain KP51069

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JW299_RS03630 Protein ID WP_002886902.1
Coordinates 370999..371283 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JW299_RS03625 Protein ID WP_002886901.1
Coordinates 370767..371009 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW299_RS03610 366796..367536 + 741 WP_002886899.1 KDGP aldolase family protein -
JW299_RS03615 367602..368756 + 1155 WP_002886900.1 lactonase family protein -
JW299_RS03620 368779..370689 + 1911 WP_004152270.1 BglG family transcription antiterminator -
JW299_RS03625 370767..371009 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JW299_RS03630 370999..371283 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW299_RS03635 371287..371751 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JW299_RS03640 371992..374130 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JW299_RS03645 374487..375230 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JW299_RS03650 375233..375406 - 174 WP_002886906.1 hypothetical protein -
JW299_RS03655 375491..375799 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T194334 WP_002886902.1 NZ_CP070564:370999-371283 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194334 NZ_CP093411:c4688321-4688010 [Salmonella enterica subsp. enterica serovar Agona]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT194334 WP_002886901.1 NZ_CP070564:370767-371009 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194334 NZ_CP093411:c4688009-4687719 [Salmonella enterica subsp. enterica serovar Agona]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGGTTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGGTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References