Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1259608..1260425 Replicon chromosome
Accession NZ_CP070553
Organism Morganella morganii strain MM50821

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag JW297_RS06325 Protein ID WP_004236532.1
Coordinates 1259943..1260425 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag JW297_RS06320 Protein ID WP_004236533.1
Coordinates 1259608..1259916 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW297_RS06295 1254914..1255120 - 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -
JW297_RS06300 1255228..1256220 - 993 WP_004240747.1 inner membrane protein YhjD -
JW297_RS06305 1256632..1257021 - 390 WP_004236536.1 DUF1090 domain-containing protein -
JW297_RS06310 1257211..1258053 + 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
JW297_RS06315 1258123..1259475 + 1353 WP_004240744.1 glutathione-disulfide reductase -
JW297_RS06320 1259608..1259916 + 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
JW297_RS06325 1259943..1260425 + 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
JW297_RS06330 1260539..1260679 - 141 WP_004236531.1 hypothetical protein -
JW297_RS06335 1260676..1261197 - 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
JW297_RS06340 1261325..1261627 - 303 WP_004240743.1 exported protein precursor -
JW297_RS06345 1261842..1262957 - 1116 WP_004240742.1 molybdenum cofactor guanylyltransferase MobA -
JW297_RS06350 1263160..1263429 + 270 WP_004240741.1 YihD family protein -
JW297_RS06355 1263429..1264424 + 996 WP_004240740.1 serine/threonine protein kinase -
JW297_RS06360 1264443..1265066 + 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T194329 WP_004236532.1 NZ_CP070553:1259943-1260425 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T194329 NZ_CP093411:3474426-3474644 [Salmonella enterica subsp. enterica serovar Agona]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT194329 WP_004236533.1 NZ_CP070553:1259608-1259916 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT194329 NZ_CP093411:3474024-3474398 [Salmonella enterica subsp. enterica serovar Agona]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References