Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 107377..108003 Replicon chromosome
Accession NZ_CP070553
Organism Morganella morganii strain MM50821

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag JW297_RS00930 Protein ID WP_024474604.1
Coordinates 107800..108003 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag JW297_RS00925 Protein ID WP_004236473.1
Coordinates 107377..107736 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW297_RS00915 102427..103623 + 1197 WP_036421099.1 efflux RND transporter periplasmic adaptor subunit -
JW297_RS00920 103638..106814 + 3177 WP_004240375.1 multidrug efflux RND transporter permease subunit -
JW297_RS00925 107377..107736 + 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
JW297_RS00930 107800..108003 + 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
JW297_RS00940 108876..109739 + 864 WP_004240378.1 acyl-CoA thioesterase II -
JW297_RS00945 109800..111089 - 1290 WP_004240381.1 ammonium transporter AmtB -
JW297_RS00950 111109..111447 - 339 WP_004236467.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T194328 WP_024474604.1 NZ_CP070553:107800-108003 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T194328 NZ_CP093411:c2749222-2749119 [Salmonella enterica subsp. enterica serovar Agona]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT194328 WP_004236473.1 NZ_CP070553:107377-107736 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT194328 NZ_CP093411:2749117-2749260 [Salmonella enterica subsp. enterica serovar Agona]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References