Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 32837..33390 Replicon plasmid p50821_KPC
Accession NZ_CP070550
Organism Morganella morganii strain MM50821

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7X5QH88
Locus tag JW297_RS00170 Protein ID WP_029403621.1
Coordinates 32837..33151 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A7X5QHA0
Locus tag JW297_RS00175 Protein ID WP_029403619.1
Coordinates 33154..33390 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW297_RS00160 30546..30722 + 177 WP_164720184.1 hypothetical protein -
JW297_RS00165 31614..32450 - 837 WP_104891177.1 replication initiation protein -
JW297_RS00170 32837..33151 - 315 WP_029403621.1 CcdB family protein Toxin
JW297_RS00175 33154..33390 - 237 WP_029403619.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JW297_RS00180 33558..33905 - 348 WP_071434319.1 hypothetical protein -
JW297_RS00185 33995..34477 - 483 WP_071434325.1 single-stranded DNA-binding protein -
JW297_RS00190 34686..34856 - 171 Protein_37 serine hydrolase -
JW297_RS00195 34911..35615 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
JW297_RS00200 35680..36204 + 525 Protein_39 Tn3 family transposase -
JW297_RS00205 36367..36450 - 84 Protein_40 SOS response-associated peptidase -
JW297_RS00210 37091..38167 - 1077 WP_000227969.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid catB3 / ARR-3 / qacE / sul1 / mph(A) / blaKPC-2 / aac(6')-Ib - 1..54347 54347
- inside IScluster/Tn catB3 / ARR-3 / qacE / sul1 / mph(A) / blaKPC-2 / aac(6')-Ib - 355..39305 38950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11602.53 Da        Isoelectric Point: 5.7681

>T194326 WP_029403621.1 NZ_CP070550:c33151-32837 [Morganella morganii]
MQFTVYSNTGKSAVYPLLIDVTSDIIGQLNRRIVIPLLPVGMYPNGMRPERLTPLIRLVDDNEYVVMTHEMASIPARSLG
AAFCDASSYRKQIKDAIDFLLDGI

Download         Length: 315 bp

>T194326 NZ_CP093411:c2398417-2398133 [Salmonella enterica subsp. enterica serovar Agona]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.12 Da        Isoelectric Point: 5.6870

>AT194326 WP_029403619.1 NZ_CP070550:c33390-33154 [Morganella morganii]
MAVTQRPMQTVTMTVKRTLLTRAREAGINLSATLTAALDAELRQYEAKRWQEENSEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT194326 NZ_CP093411:c2398655-2398407 [Salmonella enterica subsp. enterica serovar Agona]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5QH88

Antitoxin

Source ID Structure
AlphaFold DB A0A7X5QHA0

References