Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3940029..3940832 Replicon chromosome
Accession NZ_CP070549
Organism Citrobacter freundii strain CF49969

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6N6JYU3
Locus tag JW296_RS21445 Protein ID WP_024156451.1
Coordinates 3940029..3940409 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5A9BSL8
Locus tag JW296_RS21450 Protein ID WP_038807908.1
Coordinates 3940467..3940832 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW296_RS21430 3935934..3937595 - 1662 WP_048234127.1 fatty acid--CoA ligase -
JW296_RS21435 3938385..3939232 - 848 Protein_3733 DUF4942 domain-containing protein -
JW296_RS21440 3939541..3940032 - 492 WP_024156452.1 hypothetical protein -
JW296_RS21445 3940029..3940409 - 381 WP_024156451.1 TA system toxin CbtA family protein Toxin
JW296_RS21450 3940467..3940832 - 366 WP_038807908.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JW296_RS21455 3940854..3941075 - 222 WP_024156449.1 DUF987 domain-containing protein -
JW296_RS21460 3941089..3941568 - 480 WP_024156448.1 DNA repair protein RadC -
JW296_RS21465 3941581..3942054 - 474 WP_024156447.1 antirestriction protein -
JW296_RS21470 3942323..3943141 - 819 WP_048242033.1 DUF945 domain-containing protein -
JW296_RS21475 3943257..3943517 - 261 WP_048242035.1 DUF905 family protein -
JW296_RS21480 3943708..3944175 - 468 WP_048242036.1 hypothetical protein -
JW296_RS21485 3944272..3944673 - 402 WP_048242038.1 hypothetical protein -
JW296_RS21490 3944879..3945766 - 888 WP_048242072.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.44 Da        Isoelectric Point: 10.0919

>T194323 WP_024156451.1 NZ_CP070549:c3940409-3940029 [Citrobacter freundii]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

>T194323 NZ_CP093411:210108-210593 [Salmonella enterica subsp. enterica serovar Agona]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTTGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13344.20 Da        Isoelectric Point: 5.8705

>AT194323 WP_038807908.1 NZ_CP070549:c3940832-3940467 [Citrobacter freundii]
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR

Download         Length: 366 bp

>AT194323 NZ_CP093411:209833-210120 [Salmonella enterica subsp. enterica serovar Agona]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTATATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JYU3

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BSL8

References