Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2539683..2540337 Replicon chromosome
Accession NZ_CP070549
Organism Citrobacter freundii strain CF49969

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag JW296_RS14695 Protein ID WP_003026936.1
Coordinates 2539683..2540090 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag JW296_RS14700 Protein ID WP_003026938.1
Coordinates 2540071..2540337 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW296_RS14675 2535631..2537364 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
JW296_RS14680 2537370..2538083 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW296_RS14685 2538107..2539003 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
JW296_RS14690 2539117..2539638 + 522 WP_003026933.1 flavodoxin FldB -
JW296_RS14695 2539683..2540090 - 408 WP_003026936.1 protein YgfX Toxin
JW296_RS14700 2540071..2540337 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
JW296_RS14705 2540594..2541574 + 981 WP_119174530.1 tRNA-modifying protein YgfZ -
JW296_RS14710 2541668..2542327 - 660 WP_003026947.1 hemolysin III family protein -
JW296_RS14715 2542490..2542801 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
JW296_RS14720 2542854..2543582 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
JW296_RS14725 2543704..2545137 + 1434 WP_048218552.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T194317 WP_003026936.1 NZ_CP070549:c2540090-2539683 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T194317 NZ_CP093407:c4165480-4164152 [Salmonella enterica subsp. enterica serovar Agona]
ATGCGTCGAACACAGCAGCGTTTATCAATATGGATGAATGGAATCCGGGTCGGATTCTGGGAGAAGGCCAGAGGCGAGGA
TTTATTACAATACCTTCCAGAATGGATAATTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCCTTTCACTCCAGGTA
ATCAGCTTTGGCGTGGTAATGTTGTTCGTGACTATTTTGATAATTTATTGCCTGACAGCGAAAGTATACGCAGACGTTTA
GCCGTGCGTTACCAGGCTGAAAGCCTTGAGCCTTTTGATCTATTGGCTGAGCTGGGAAGAGACTGCGTTGGTGCAATACA
GTTACTGAATGTTGATGAAGAGCCCACAGATTTATTTTCCGTAAATTATCGCCCACTTTCTGAAGCTGATATCGCAACTA
CATTGCGTAATACTACGGCGATATCGTTGCCTGGTCGGCAGGACGAAACTGACGATTTGCGATTATCAATTGCCGGTGCG
CAGGAAAAAACGGCTTTATTGTGGCATGAAGAACGATGGTGTTTACCTGAAGGTAATACCCCAACAACGCATATCTTCAA
ACTACCGCTTGGGTTGGTTGGGAACATGCAAGCGGATATGAGTACATCGGTTGAAAATGAATGGCTGTGTTCTTTGCTTG
TTGAGCACTACGGGATCCCTGTAGCAAAAACACAGATTGCGCAGTTTGAGGATCAGAAGGCATTAGTAGTTGAGCGTTTC
GACAGAAGATGGTCAGGCGATCGGCAATGGATCATTCGTTTGCCACAAGAGGATATGTGTCAGGCTTTAGGTGTTTCTCC
GTTACGAAAATACCAGTCTGATGGTGGGCCGGGTATTTCCGATATTATGGAAATACTGAGTCATTCAGATCAGGCTGAGC
AGGACAAAGAGCAGTTCTTCAGGGCTCAAATTATTTTCTGGTTGATGGCTGCTACTGACGGCCATGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAAGTCGTTACCACCTTACGCCTCTTTACGATATTTTATCAGCATGGCCGGTAATTGGTCATGG
TAATAATCAGATTTCCTGGCAAAGATGCAAACTGGCAATGGCTGTTCGCGGTAGCAGTAATTATTACCACATTTATAGAG
TTCAACGACGGCATTGGATTAATCAAGGTGAATTAAACGGATTGGGAAGACGACAAGTTGAGTCCATGATGGATGACATT
ATATCCAGCACACCTGAAGTCATTGAGCGTGTATCTGCGTTGCTTCCAGAGTCGTTTCCATCTGAGCTTGCTGAGTGTAT
TTTTGAAGGTATGCGGCAGCAGTGTAGGCGTTTGGCTGGAAGGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT194317 WP_003026938.1 NZ_CP070549:c2540337-2540071 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194317 NZ_CP093407:c4165790-4165485 [Salmonella enterica subsp. enterica serovar Agona]
ATGAATACTGTTTATCCGTTGAAAACTTTGAATCAAATTCGTCCATTGCTGATTGGCTTTCGCAAGGCTAATGGACTGAC
ACAAAAGGAAGTTTCTGAAAGGTTAGGAGTAACTCAGCAAACTTATGCCCGACTGGAAGCGAATCCAGCCAGTGCCAGTA
TGGAGCGACTATTCAGGGTATTTACCGTGCTGGGTGTAGAAATGGTACTCTCTTCTGGGCCACAGATACTTTCTTCGATG
TCATCTTCAACAATGGAAGAGTCAGAACAGCAAATAGATTCACCTGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References