194302

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3146819..3147445 Replicon chromosome
Accession NZ_CP070537
Organism Morganella morganii strain MM48659

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag JW294_RS15390 Protein ID WP_024474604.1
Coordinates 3146819..3147022 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag JW294_RS15395 Protein ID WP_004236473.1
Coordinates 3147086..3147445 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW294_RS15370 3143375..3143713 + 339 WP_004236467.1 P-II family nitrogen regulator -
JW294_RS15375 3143733..3145022 + 1290 WP_036415555.1 ammonium transporter AmtB -
JW294_RS15380 3145083..3145946 - 864 WP_004240378.1 acyl-CoA thioesterase II -
JW294_RS15390 3146819..3147022 - 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
JW294_RS15395 3147086..3147445 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
JW294_RS15405 3149269..3152445 - 3177 WP_004240375.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T194302 WP_024474604.1 NZ_CP070537:c3147022-3146819 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T194302 NZ_CP093405:3756728-3756985 [Salmonella enterica subsp. enterica serovar Agona]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGTATAACCACCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCACAGGGGTGTA
TTGTGCTAATGGCGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACGGGTGGTTAAGGGGTTG
AAGGATGTACTGGTTTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT194302 WP_004236473.1 NZ_CP070537:c3147445-3147086 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT194302 NZ_CP093405:c3756949-3756571 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References