Detailed information of TA system TA194287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2451200..2452113
• Replicon: chromosome
• Accession: NZ_CP070534
• Organism: Enterobacter hormaechei strain EC48293

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JW293_RS13765
• Protein ID: WP_032647883.1
• Coordinates: 2451200..2451673 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JW293_RS13770
• Protein ID: WP_023296216.1
• Coordinates: 2451670..2452113 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW293_RS13745	2447359..2448669	+	1311	WP_032647879.1	type I-F CRISPR-associated protein Csy1	-
JW293_RS13750	2448666..2449601	+	936	WP_032647880.1	type I-F CRISPR-associated protein Csy2	-
JW293_RS13755	2449615..2450613	+	999	WP_032647881.1	type I-F CRISPR-associated protein Csy3	-
JW293_RS13760	2450623..2451177	+	555	WP_032647882.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
JW293_RS13765	2451200..2451673	-	474	WP_032647883.1	RES domain-containing protein	Toxin
JW293_RS13770	2451670..2452113	-	444	WP_023296216.1	DUF2384 domain-containing protein	Antitoxin
JW293_RS13775	2453211..2453429	-	219	WP_002211347.1	translation initiation factor IF-1	-
JW293_RS13780	2453714..2454418	-	705	WP_032647884.1	leucyl/phenylalanyl-tRNA--protein transferase	-
JW293_RS13785	2454464..2456185	-	1722	WP_032647885.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17569.96 Da
• Isoelectric Point: 5.5555

>T194287 WP_032647883.1 NZ_CP070534:c2451673-2451200 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFNFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T194287 NZ_CP093403:c2777081-2776978 [Salmonella enterica subsp. enterica serovar Agona]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16512.81 Da
• Isoelectric Point: 6.4819

>AT194287 WP_023296216.1 NZ_CP070534:c2452113-2451670 [Enterobacter hormaechei]
MRTWVPAQRPADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT194287 NZ_CP093403:2776976-2777119 [Salmonella enterica subsp. enterica serovar Agona]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG