194285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1765516..1766231 Replicon chromosome
Accession NZ_CP070534
Organism Enterobacter hormaechei strain EC48293

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8I0UM05
Locus tag JW293_RS10445 Protein ID WP_023303149.1
Coordinates 1765863..1766231 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0UJV2
Locus tag JW293_RS10440 Protein ID WP_023303148.1
Coordinates 1765516..1765842 (+) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW293_RS10415 1760550..1761815 + 1266 WP_045324920.1 hypothetical protein -
JW293_RS10420 1762124..1762558 + 435 WP_023303144.1 hypothetical protein -
JW293_RS10425 1762617..1763456 + 840 WP_023303145.1 hypothetical protein -
JW293_RS10430 1764146..1764967 + 822 WP_023303146.1 DUF945 domain-containing protein -
JW293_RS10435 1765033..1765503 + 471 WP_023303147.1 DNA repair protein RadC -
JW293_RS10440 1765516..1765842 + 327 WP_023303148.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JW293_RS10445 1765863..1766231 + 369 WP_023303149.1 TA system toxin CbtA family protein Toxin
JW293_RS10450 1766581..1767327 - 747 WP_032647364.1 class I SAM-dependent methyltransferase -
JW293_RS10455 1767338..1767595 - 258 WP_003863178.1 YjhX family toxin -
JW293_RS10460 1767855..1769549 - 1695 Protein_1605 bifunctional diguanylate cyclase/phosphodiesterase -
JW293_RS10465 1769875..1770861 + 987 WP_058671381.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1744598..1780642 36044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-111)

Antitoxin

(7-107)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.91 Da        Isoelectric Point: 8.2822

>T194285 WP_023303149.1 NZ_CP070534:1765863-1766231 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Download         Length: 369 bp

>T194285 NZ_CP093403:c2426276-2425992 [Salmonella enterica subsp. enterica serovar Agona]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12215.04 Da        Isoelectric Point: 7.0266

>AT194285 WP_023303148.1 NZ_CP070534:1765516-1765842 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 327 bp

>AT194285 NZ_CP093403:c2426514-2426266 [Salmonella enterica subsp. enterica serovar Agona]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References