Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 558720..559324 Replicon chromosome
Accession NZ_CP070534
Organism Enterobacter hormaechei strain EC48293

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag JW293_RS04835 Protein ID WP_071788668.1
Coordinates 559139..559324 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag JW293_RS04830 Protein ID WP_023295606.1
Coordinates 558720..559124 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW293_RS04815 554260..555078 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
JW293_RS04820 555304..556704 + 1401 WP_204622493.1 glycoside-pentoside-hexuronide (GPH):cation symporter -
JW293_RS04825 556715..558664 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
JW293_RS04830 558720..559124 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JW293_RS04835 559139..559324 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
JW293_RS04840 559574..561112 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
JW293_RS04845 561279..562163 + 885 WP_003860164.1 ROK family protein -
JW293_RS04850 562167..564005 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T194282 WP_071788668.1 NZ_CP070534:c559324-559139 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T194282 NZ_CP093403:210108-210593 [Salmonella enterica subsp. enterica serovar Agona]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTTGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT194282 WP_023295606.1 NZ_CP070534:c559124-558720 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT194282 NZ_CP093403:209833-210120 [Salmonella enterica subsp. enterica serovar Agona]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTATATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References