Detailed information of TA system TA194275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2717363..2718951
• Replicon: chromosome
• Accession: NZ_CP070528
• Organism: Klebsiella pneumoniae strain KP47693

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JW292_RS13980
• Protein ID: WP_004184027.1
• Coordinates: 2717363..2718685 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JW292_RS13985
• Protein ID: WP_004176198.1
• Coordinates: 2718685..2718951 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW292_RS13965	2712419..2714920	+	2502	WP_032418977.1	fimbrial biogenesis outer membrane usher protein	-
JW292_RS13970	2714908..2715912	+	1005	WP_016946380.1	type 1 fimbrial protein	-
JW292_RS13975	2716054..2717346	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
JW292_RS13980	2717363..2718685	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
JW292_RS13985	2718685..2718951	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JW292_RS13990	2719217..2719543	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
JW292_RS13995	2719540..2720040	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JW292_RS14000	2720018..2721397	-	1380	WP_032418979.1	purine permease	-
JW292_RS14005	2721743..2722897	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
JW292_RS14010	2722878..2723801	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T194275 WP_004184027.1 NZ_CP070528:c2718685-2717363 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T194275 NZ_CP093402:3597085-3597303 [Salmonella enterica subsp. enterica serovar Agona]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT194275 WP_004176198.1 NZ_CP070528:c2718951-2718685 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT194275 NZ_CP093402:3596683-3597057 [Salmonella enterica subsp. enterica serovar Agona]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA