Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811615..812272 Replicon chromosome
Accession NZ_CP070528
Organism Klebsiella pneumoniae strain KP47693

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JW292_RS04695 Protein ID WP_002916310.1
Coordinates 811862..812272 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JW292_RS04690 Protein ID WP_002916312.1
Coordinates 811615..811881 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW292_RS04665 806771..808204 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
JW292_RS04670 808323..809051 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JW292_RS04675 809101..809412 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JW292_RS04680 809576..810235 + 660 WP_002916317.1 hemolysin III family protein -
JW292_RS04685 810386..811369 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JW292_RS04690 811615..811881 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JW292_RS04695 811862..812272 + 411 WP_002916310.1 protein YgfX Toxin
JW292_RS04700 812279..812800 - 522 WP_004144730.1 flavodoxin FldB -
JW292_RS04705 812901..813797 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JW292_RS04710 813820..814533 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW292_RS04715 814539..816272 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194265 WP_002916310.1 NZ_CP070528:811862-812272 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194265 NZ_CP093401:14789-15121 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194265 WP_002916312.1 NZ_CP070528:811615-811881 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194265 NZ_CP093401:14531-14788 [Salmonella enterica subsp. enterica serovar Infantis]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References