Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3761497..3762314 Replicon chromosome
Accession NZ_CP070524
Organism Morganella morganii strain MM46903

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag JW291_RS18790 Protein ID WP_004236532.1
Coordinates 3761497..3761979 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag JW291_RS18795 Protein ID WP_004236533.1
Coordinates 3762006..3762314 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW291_RS18755 3756856..3757479 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
JW291_RS18760 3757498..3758493 - 996 WP_004240740.1 serine/threonine protein kinase -
JW291_RS18765 3758493..3758762 - 270 WP_004240741.1 YihD family protein -
JW291_RS18770 3758965..3760080 + 1116 WP_004240742.1 molybdenum cofactor guanylyltransferase MobA -
JW291_RS18775 3760295..3760597 + 303 WP_004240743.1 exported protein precursor -
JW291_RS18780 3760725..3761246 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
JW291_RS18785 3761243..3761383 + 141 WP_004236531.1 hypothetical protein -
JW291_RS18790 3761497..3761979 - 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
JW291_RS18795 3762006..3762314 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
JW291_RS18800 3762447..3763799 - 1353 WP_004240744.1 glutathione-disulfide reductase -
JW291_RS18805 3763869..3764711 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
JW291_RS18810 3764901..3765290 + 390 WP_004236536.1 DUF1090 domain-containing protein -
JW291_RS18815 3765702..3766694 + 993 WP_004240747.1 inner membrane protein YhjD -
JW291_RS18820 3766802..3767008 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T194262 WP_004236532.1 NZ_CP070524:c3761979-3761497 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T194262 NZ_CP093400:c4183106-4182822 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT194262 WP_004236533.1 NZ_CP070524:c3762314-3762006 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT194262 NZ_CP093400:c4183338-4183096 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCCTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGAATTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References