Detailed information of TA system TA194262

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3761497..3762314
• Replicon: chromosome
• Accession: NZ_CP070524
• Organism: Morganella morganii strain MM46903

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A2C5TM43
• Locus tag: JW291_RS18790
• Protein ID: WP_004236532.1
• Coordinates: 3761497..3761979 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: J7TDK6
• Locus tag: JW291_RS18795
• Protein ID: WP_004236533.1
• Coordinates: 3762006..3762314 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW291_RS18755	3756856..3757479	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
JW291_RS18760	3757498..3758493	-	996	WP_004240740.1	serine/threonine protein kinase	-
JW291_RS18765	3758493..3758762	-	270	WP_004240741.1	YihD family protein	-
JW291_RS18770	3758965..3760080	+	1116	WP_004240742.1	molybdenum cofactor guanylyltransferase MobA	-
JW291_RS18775	3760295..3760597	+	303	WP_004240743.1	exported protein precursor	-
JW291_RS18780	3760725..3761246	+	522	WP_015422407.1	isopentenyl-diphosphate Delta-isomerase	-
JW291_RS18785	3761243..3761383	+	141	WP_004236531.1	hypothetical protein	-
JW291_RS18790	3761497..3761979	-	483	WP_004236532.1	GNAT family N-acetyltransferase	Toxin
JW291_RS18795	3762006..3762314	-	309	WP_004236533.1	DUF1778 domain-containing protein	Antitoxin
JW291_RS18800	3762447..3763799	-	1353	WP_004240744.1	glutathione-disulfide reductase	-
JW291_RS18805	3763869..3764711	-	843	WP_004236535.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
JW291_RS18810	3764901..3765290	+	390	WP_004236536.1	DUF1090 domain-containing protein	-
JW291_RS18815	3765702..3766694	+	993	WP_004240747.1	inner membrane protein YhjD	-
JW291_RS18820	3766802..3767008	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (36-135)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17729.48 Da
• Isoelectric Point: 10.2370

>T194262 WP_004236532.1 NZ_CP070524:c3761979-3761497 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Nucleotide

• Length: 483 bp

>T194262 NZ_CP093400:c4183106-4182822 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11499.15 Da
• Isoelectric Point: 8.6397

>AT194262 WP_004236533.1 NZ_CP070524:c3762314-3762006 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT194262 NZ_CP093400:c4183338-4183096 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCCTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGAATTA
TGA

Structures

Toxin

• AlphaFold DB: A0A2C5TM43

Antitoxin

• AlphaFold DB: J7TDK6