Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 8754..9307 Replicon plasmid p46903_KPC
Accession NZ_CP070521
Organism Morganella morganii strain MM46903

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7X5QH88
Locus tag JW291_RS00075 Protein ID WP_029403621.1
Coordinates 8993..9307 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A7X5QHA0
Locus tag JW291_RS00070 Protein ID WP_029403619.1
Coordinates 8754..8990 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW291_RS00035 3977..5053 + 1077 WP_000227969.1 IS110 family transposase -
JW291_RS00040 5694..5777 + 84 Protein_7 SOS response-associated peptidase -
JW291_RS00045 5940..6464 - 525 Protein_8 Tn3 family transposase -
JW291_RS00050 6529..7233 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
JW291_RS00055 7288..7458 + 171 Protein_10 serine hydrolase -
JW291_RS00060 7667..8149 + 483 WP_071434325.1 single-stranded DNA-binding protein -
JW291_RS00065 8239..8586 + 348 WP_071434319.1 hypothetical protein -
JW291_RS00070 8754..8990 + 237 WP_029403619.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JW291_RS00075 8993..9307 + 315 WP_029403621.1 CcdB family protein Toxin
JW291_RS00080 9694..10530 + 837 WP_104891177.1 replication initiation protein -
JW291_RS00085 11422..11598 - 177 WP_164720184.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-Ib / blaKPC-2 / mph(A) / sul1 / qacE / ARR-3 / catB3 - 1..54351 54351
- inside IScluster/Tn aac(6')-Ib / blaKPC-2 / mph(A) / sul1 / qacE / ARR-3 / catB3 - 2839..45035 42196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11602.53 Da        Isoelectric Point: 5.7681

>T194258 WP_029403621.1 NZ_CP070521:8993-9307 [Morganella morganii]
MQFTVYSNTGKSAVYPLLIDVTSDIIGQLNRRIVIPLLPVGMYPNGMRPERLTPLIRLVDDNEYVVMTHEMASIPARSLG
AAFCDASSYRKQIKDAIDFLLDGI

Download         Length: 315 bp

>T194258 NZ_CP093400:c2298411-2298127 [Salmonella enterica subsp. enterica serovar Infantis]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.12 Da        Isoelectric Point: 5.6870

>AT194258 WP_029403619.1 NZ_CP070521:8754-8990 [Morganella morganii]
MAVTQRPMQTVTMTVKRTLLTRAREAGINLSATLTAALDAELRQYEAKRWQEENSEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT194258 NZ_CP093400:c2298649-2298401 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGAGGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5QH88

Antitoxin

Source ID Structure
AlphaFold DB A0A7X5QHA0

References