Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1992..2635 Replicon plasmid p46903_KPC
Accession NZ_CP070521
Organism Morganella morganii strain MM46903

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag JW291_RS00025 Protein ID WP_000754566.1
Coordinates 2219..2635 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag JW291_RS00020 Protein ID WP_001261276.1
Coordinates 1992..2222 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW291_RS00010 274..1017 - 744 WP_000129823.1 hypothetical protein -
JW291_RS00015 1068..1418 - 351 WP_000493378.1 hypothetical protein -
JW291_RS00020 1992..2222 + 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JW291_RS00025 2219..2635 + 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
JW291_RS00030 2839..3695 + 857 Protein_5 IS3-like element ISEc15 family transposase -
JW291_RS00035 3977..5053 + 1077 WP_000227969.1 IS110 family transposase -
JW291_RS00040 5694..5777 + 84 Protein_7 SOS response-associated peptidase -
JW291_RS00045 5940..6464 - 525 Protein_8 Tn3 family transposase -
JW291_RS00050 6529..7233 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
JW291_RS00055 7288..7458 + 171 Protein_10 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-Ib / blaKPC-2 / mph(A) / sul1 / qacE / ARR-3 / catB3 - 1..54351 54351
- inside IScluster/Tn aac(6')-Ib / blaKPC-2 / mph(A) / sul1 / qacE / ARR-3 / catB3 - 2839..45035 42196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T194257 WP_000754566.1 NZ_CP070521:2219-2635 [Morganella morganii]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T194257 NZ_CP093400:1603978-1604130 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT194257 WP_001261276.1 NZ_CP070521:1992-2222 [Morganella morganii]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT194257 NZ_CP093400:c1603926-1603866 [Salmonella enterica subsp. enterica serovar Infantis]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References