Detailed information of TA system TA194254

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2641381..2642038
• Replicon: chromosome
• Accession: NZ_CP070520
• Organism: Klebsiella aerogenes strain EA46506

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JW290_RS13070
• Protein ID: WP_020077981.1
• Coordinates: 2641381..2641791 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0H3FJK6
• Locus tag: JW290_RS13075
• Protein ID: WP_015369791.1
• Coordinates: 2641772..2642038 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW290_RS13050	2637380..2639113	-	1734	WP_015369796.1	single-stranded-DNA-specific exonuclease RecJ	-
JW290_RS13055	2639119..2639832	-	714	WP_015369795.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JW290_RS13060	2639855..2640751	-	897	WP_015703420.1	site-specific tyrosine recombinase XerD	-
JW290_RS13065	2640852..2641373	+	522	WP_015369793.1	flavodoxin FldB	-
JW290_RS13070	2641381..2641791	-	411	WP_020077981.1	protein YgfX	Toxin
JW290_RS13075	2641772..2642038	-	267	WP_015369791.1	FAD assembly factor SdhE	Antitoxin
JW290_RS13080	2642262..2643245	+	984	WP_015369790.1	tRNA-modifying protein YgfZ	-
JW290_RS13085	2643344..2644003	-	660	WP_008806429.1	hemolysin III family protein	-
JW290_RS13090	2644168..2644479	-	312	WP_015703422.1	N(4)-acetylcytidine aminohydrolase	-
JW290_RS13095	2644530..2645264	+	735	WP_015703423.1	MurR/RpiR family transcriptional regulator	-
JW290_RS13100	2645378..2646811	+	1434	WP_015369787.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15873.66 Da
• Isoelectric Point: 10.0200

>T194254 WP_020077981.1 NZ_CP070520:c2641791-2641381 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAESGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Nucleotide

• Length: 411 bp

>T194254 NZ_CP093400:847109-847522 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10579.09 Da
• Isoelectric Point: 5.6963

>AT194254 WP_015369791.1 NZ_CP070520:c2642038-2641772 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT194254 NZ_CP093400:846862-847128 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3FJK6