Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 934470..935209 Replicon chromosome
Accession NZ_CP070520
Organism Klebsiella aerogenes strain EA46506

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag JW290_RS04960 Protein ID WP_015705365.1
Coordinates 934470..934955 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag JW290_RS04965 Protein ID WP_015705366.1
Coordinates 934943..935209 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW290_RS04940 930017..931087 - 1071 WP_205460569.1 mannonate dehydratase -
JW290_RS04945 931348..931506 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
JW290_RS04950 931563..932663 - 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
JW290_RS04955 932782..934398 - 1617 WP_205460570.1 FAD-NAD(P)-binding protein -
JW290_RS04960 934470..934955 - 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
JW290_RS04965 934943..935209 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
JW290_RS04970 935482..936717 + 1236 WP_058674263.1 MFS transporter -
JW290_RS04975 936761..937258 - 498 WP_015705368.1 heme-binding protein -
JW290_RS04980 937354..937971 - 618 WP_205460571.1 response regulator -
JW290_RS04985 937971..939290 - 1320 WP_205460572.1 sensor histidine kinase -
JW290_RS04990 939287..939874 - 588 WP_032705775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T194244 WP_015705365.1 NZ_CP070520:c934955-934470 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T194244 NZ_CP093392:c4511186-4510812 [Salmonella enterica]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACTTGTTTAGCGGTCGTATCGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCGAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT194244 WP_015705366.1 NZ_CP070520:c935209-934943 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT194244 NZ_CP093392:c4511428-4511186 [Salmonella enterica]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAGGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References