Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3841096..3842732 Replicon chromosome
Accession NZ_CP070518
Organism Acinetobacter calcoaceticus strain FDAARGOS_1218

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag I6J48_RS17995 Protein ID WP_205469231.1
Coordinates 3841096..3842427 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6J48_RS18000 Protein ID WP_005040627.1
Coordinates 3842424..3842732 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J48_RS17980 3836685..3837320 - 636 WP_205469228.1 3'-5' exonuclease -
I6J48_RS17985 3837587..3838582 - 996 WP_205469229.1 putative multidrug efflux protein AdeT1 -
I6J48_RS17990 3839106..3840878 + 1773 WP_205469230.1 amidohydrolase family protein -
I6J48_RS17995 3841096..3842427 + 1332 WP_205469231.1 HipA domain-containing protein Toxin
I6J48_RS18000 3842424..3842732 + 309 WP_005040627.1 helix-turn-helix domain-containing protein Antitoxin
I6J48_RS18005 3842831..3845092 - 2262 WP_205469232.1 ATP-binding cassette domain-containing protein -
I6J48_RS18010 3845360..3845596 - 237 WP_205469233.1 VF530 family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-358)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50830.72 Da        Isoelectric Point: 5.1365

>T194242 WP_205469231.1 NZ_CP070518:3841096-3842427 [Acinetobacter calcoaceticus]
MKKLTIQALLDANWLDIAELKLLESKQGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILVKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQENFDQPDQHYLVKFPRNKRSEIDCDILRAEYCYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWRNQQWHRHGLESVYSVLNKSSGSHLNHFDVIDDLCNLLTRIDSDFDASQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKFAPWCDPDLSLGTLK
SLAINLLGLKQRLVDKGVPKKIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T194242 NZ_CP093392:4204112-4205041 [Salmonella enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTCAGGCTATTAATGACCGCCCTGCCGCATGTAGCAAAGGAGTCCTGCTT
CGCCCTGAAAGGCGGCACGGCAATAAATTTGTTTGTGCAGGATTTCCCTCGCCTCTCGGTAGATATCGATCTGGCGTACA
AGACCTATGCGGATCGCGATACCGATCTGGCTGCCATCAATGACGCCTTAATGCGCATTACGGAATCGCTGAACGACAGA
CCGGGGATCAGTGCTATCCGACAGGAGAATAAAGCGGATGAAAAGCGCATCATCGTCAACACCGCTGACGCGAAGATAAA
GATTGAGGTTAGTCCGGTCTGGCGTGGACTACTATTACCACCAACAGAAATGCCGGTATGTGAACAGGTGGAAATTGAAT
ATGGCTTCACCACCATGAATGTCGTCTCGCTGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTGCTGAATATGCTGGAAAAGCCGGGCCTGACGCGTGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGGCATCCCCGCCCCATTACCGAGCTGCTGGCACCAAACTGGGATACAGCGCGGATCACTACCCTGTACGCAC
AGGAATTTTCAGGCATGACACAGCAGGAAACATCGCTGGAATCCCTTTTATCAGTAACGACTTTGCTGCCACAAGCGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCCGCTATAAGCAAAATACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCAGCGATTCGCTGGAAGTCGCGTAACCTGGCGGTGCTGAAGGATAAGAATCCGGCCAAGT
ATGCGGCGGCGGTGAATAAGCTGGAGAGAGTTCTGGAGCAGTACCTTTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11504.43 Da        Isoelectric Point: 10.0639

>AT194242 WP_005040627.1 NZ_CP070518:3842424-3842732 [Acinetobacter calcoaceticus]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSHLRKNVLGLSQEQYAALVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKPSE

Download         Length: 309 bp

>AT194242 NZ_CP093392:4203343-4204125 [Salmonella enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAGAACACCCTCCCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGTAATGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCGCACGGCGTATACTGCCGGACGG
GCCGTGAACCAGACTGGGTGGACGCAGTTTACTGCCTGCAAACGCAGTGGGAAAAGCCAGTTCGCATGGCCGGGCTGACC
AGCCTTGCGCTACAGGGCTATGCCCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTGGCACTTCCGGCTTACGCCAA
ACTGCCGGGATGGTTTGTCGCCTTTGAGCAATCCGCGATGTTTGTCACACTGTATACCTCTGGTCTCACCGTCGATATAA
CACCATTCACGACAAAACTGAATATCGGCGACCGGCAGTTAATAGGCAGTGTCCCAGAACTGGCCGCGTATGAGATCGCC
TGCGGAGTACCCTCGTTGATCTCATTCGAACATGCCGACGCTCTGTTTCAGGGAATGAATCTTCTCAGCCCGCGAAAATT
ACAGGCTTTGCTCTGCGCCAGCCATTCAGTTAAAACCAACCGGGTGATGCTCTATCTTGCCCGACGCAACGAGCACCCTT
ACTTTCAGTACCTCGATCAAAGCGGTATAGAAACAGGCACTGGAAAACGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References