Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 261800..262436 Replicon chromosome
Accession NZ_CP070511
Organism Parageobacillus toebii strain NEB718

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag JTI59_RS01235 Protein ID WP_003253417.1
Coordinates 261800..262150 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag JTI59_RS01240 Protein ID WP_003253419.1
Coordinates 262155..262436 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTI59_RS01220 258639..259106 - 468 WP_012748967.1 SprT family protein -
JTI59_RS01225 259195..259308 + 114 WP_012748966.1 cortex morphogenetic protein CmpA -
JTI59_RS01230 259303..261468 - 2166 WP_187252148.1 RNA-binding transcriptional accessory protein -
JTI59_RS01235 261800..262150 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JTI59_RS01240 262155..262436 - 282 WP_003253419.1 hypothetical protein Antitoxin
JTI59_RS01245 262565..263728 - 1164 WP_062678764.1 alanine racemase -
JTI59_RS01250 263952..264965 - 1014 WP_081189843.1 outer membrane lipoprotein carrier protein LolA -
JTI59_RS01255 265047..265406 - 360 WP_062756414.1 holo-ACP synthase -
JTI59_RS01260 265466..266083 + 618 WP_062678766.1 rhomboid family intramembrane serine protease -
JTI59_RS01265 266121..266468 - 348 WP_205424229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T194241 WP_003253417.1 NZ_CP070511:c262150-261800 [Parageobacillus toebii]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T194241 NZ_CP093392:c4087999-4087715 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGGACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT194241 WP_003253419.1 NZ_CP070511:c262436-262155 [Parageobacillus toebii]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT194241 NZ_CP093392:c4088231-4087989 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGATA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A178U3Z0

References