Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 33297..33819 Replicon plasmid unnamed1
Accession NZ_CP070509
Organism Serratia ureilytica strain AM923

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IHE77_RS25040 Protein ID WP_241440765.1
Coordinates 33297..33578 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IHE77_RS25045 Protein ID WP_085337699.1
Coordinates 33568..33819 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHE77_RS25000 (IHE77_24950) 28953..29510 - 558 WP_241440758.1 DNA distortion polypeptide 1 -
IHE77_RS25005 (IHE77_24955) 29973..30176 - 204 WP_085337694.1 hypothetical protein -
IHE77_RS25010 (IHE77_24960) 30372..30581 - 210 WP_085337717.1 hypothetical protein -
IHE77_RS25015 (IHE77_24965) 30708..30893 - 186 WP_139831044.1 hypothetical protein -
IHE77_RS25020 (IHE77_24970) 31008..31523 - 516 WP_241440760.1 DnaJ domain-containing protein -
IHE77_RS25025 32005..32436 - 432 WP_230298461.1 hypothetical protein -
IHE77_RS25030 (IHE77_24985) 32433..32702 - 270 WP_241440762.1 hypothetical protein -
IHE77_RS25035 (IHE77_24990) 32695..33255 - 561 WP_085337697.1 hypothetical protein -
IHE77_RS25040 (IHE77_24995) 33297..33578 - 282 WP_241440765.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHE77_RS25045 (IHE77_25000) 33568..33819 - 252 WP_085337699.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IHE77_RS25050 (IHE77_25005) 33889..34581 - 693 WP_241440766.1 hypothetical protein -
IHE77_RS25055 (IHE77_25010) 35630..36568 + 939 WP_241440768.1 replication initiation protein -
IHE77_RS25060 (IHE77_25015) 36578..37030 + 453 WP_241440770.1 hypothetical protein -
IHE77_RS25065 (IHE77_25020) 37262..37627 + 366 WP_241440772.1 DUF2726 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38329 38329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10948.86 Da        Isoelectric Point: 10.7594

>T194240 WP_241440765.1 NZ_CP070509:c33578-33297 [Serratia ureilytica]
MTYKLKFEKRALKEWEKLGHPIREQLKKKLAERLENPHVPASRLSGRQNRYKIKLRSSGYRLVYQVIDNEIVLLVIAVGK
RAGDEVYLTADKR

Download         Length: 282 bp

>T194240 NZ_CP093392:c4030335-4030027 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9191.29 Da        Isoelectric Point: 3.8189

>AT194240 WP_085337699.1 NZ_CP070509:c33819-33568 [Serratia ureilytica]
MAYQILTTTAASITDLKKNPMGTVADGDGEAIAILNRNEPAFYCVPPELFAYYRELAEDAELNQIADERMKDAEYVSVSL
DDL

Download         Length: 252 bp

>AT194240 NZ_CP093392:c4030577-4030338 [Salmonella enterica]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References