Detailed information of TA system TA194238

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4230654..4231323
• Replicon: chromosome
• Accession: NZ_CP070508
• Organism: Serratia ureilytica strain AM923

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IHE77_RS20260
• Protein ID: WP_142002924.1
• Coordinates: 4230654..4231076 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: IHE77_RS20265
• Protein ID: WP_019455657.1
• Coordinates: 4231057..4231323 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHE77_RS20240 (IHE77_20200)	4226581..4228314	-	1734	WP_241439486.1	single-stranded-DNA-specific exonuclease RecJ	-
IHE77_RS20245 (IHE77_20205)	4228321..4229037	-	717	WP_042785306.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
IHE77_RS20250 (IHE77_20210)	4229064..4229963	-	900	WP_142003309.1	site-specific tyrosine recombinase XerD	-
IHE77_RS20255 (IHE77_20215)	4230070..4230588	+	519	WP_033635825.1	flavodoxin FldB	-
IHE77_RS20260 (IHE77_20220)	4230654..4231076	-	423	WP_142002924.1	protein YgfX	Toxin
IHE77_RS20265 (IHE77_20225)	4231057..4231323	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
IHE77_RS20270 (IHE77_20230)	4231644..4232636	+	993	WP_047573794.1	tRNA-modifying protein YgfZ	-
IHE77_RS20275 (IHE77_20235)	4232675..4233172	-	498	WP_033644774.1	DUF2165 domain-containing protein	-
IHE77_RS20280 (IHE77_20240)	4233323..4233997	-	675	WP_033644772.1	hemolysin III family protein	-
IHE77_RS20285 (IHE77_20245)	4234181..4234789	+	609	WP_033652170.1	HD domain-containing protein	-
IHE77_RS20290 (IHE77_20250)	4234822..4235748	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16469.45 Da
• Isoelectric Point: 10.6021

>T194238 WP_142002924.1 NZ_CP070508:c4231076-4230654 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWQLAKKPWMPGYGLLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQD

Nucleotide

• Length: 423 bp

>T194238 NZ_CP093392:c2111745-2111467 [Salmonella enterica]
ATGATTAAAAGCTTCAGACATAAGGGACTGAAAAAGTTCTATCAAAAAGGCGACAGCAGCGGTTTAGAACAATCACTGGT
CCCGCGCCTGAAAAACAGGTTATCCATGCTGGATGCAGCAAAGACAATTGATTTCCTGAATCAGCAAGGCTACGACCTTC
ATGAGCTTAAAGGCGATCGTGCTGAAACGTGGTCCATAAAAGTTTCTGGTAACTGGCGTCTGACGTTTATCTTTGAAAAC
GGTGACGTCTACGTTCTCAACCTGGAGGATTATCACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT194238 WP_019455657.1 NZ_CP070508:c4231323-4231057 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT194238 NZ_CP093392:c2111467-2111183 [Salmonella enterica]
ATGGCTATGTTCGATCCTGCTTACCCTGGCGAAATCATTGCCGAAATTCTGGAAGACCAGGGCGTAAGCCTGCGTCAGTT
TGCTGTAGCTATGAATATTGCGCCATCAACCGCCAGCCGTATTCTGAGCGGTAAAGTAAGTATCACGCCAGAAATGGCGG
TTAAGCTGGCTATCGTTCTTGGCGGCGATGCCGAAAGCTGGCTTAACCTTCAGAATAACTACAGTCTGTCGCAGGCACGT
AAAACAGTGGATATAACTCATGTTCACCGTCTGTCTTTTGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04