Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1767873..1768398 Replicon chromosome
Accession NZ_CP070508
Organism Serratia ureilytica strain AM923

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GJ35
Locus tag IHE77_RS08485 Protein ID WP_033633469.1
Coordinates 1767873..1768157 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag IHE77_RS08490 Protein ID WP_004928423.1
Coordinates 1768147..1768398 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHE77_RS08460 (IHE77_08450) 1763077..1764210 + 1134 WP_004938650.1 putrescine ABC transporter ATP-binding subunit PotG -
IHE77_RS08465 (IHE77_08455) 1764235..1765197 + 963 WP_142002224.1 putrescine ABC transporter permease PotH -
IHE77_RS08470 (IHE77_08460) 1765194..1766039 + 846 WP_025302238.1 putrescine ABC transporter permease PotI -
IHE77_RS08475 (IHE77_08465) 1766201..1766680 + 480 WP_047024958.1 YbjO family protein -
IHE77_RS08480 (IHE77_08470) 1766749..1767876 + 1128 WP_033650649.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
IHE77_RS08485 (IHE77_08475) 1767873..1768157 - 285 WP_033633469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IHE77_RS08490 (IHE77_08480) 1768147..1768398 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
IHE77_RS08495 (IHE77_08485) 1768500..1769234 - 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
IHE77_RS08500 (IHE77_08490) 1769434..1770102 - 669 WP_033650651.1 arginine ABC transporter permease ArtM -
IHE77_RS08505 (IHE77_08495) 1770102..1770818 - 717 WP_025159684.1 arginine ABC transporter permease ArtQ -
IHE77_RS08510 (IHE77_08500) 1770828..1771559 - 732 WP_033642533.1 arginine ABC transporter substrate-binding protein -
IHE77_RS08515 (IHE77_08505) 1771592..1772320 - 729 WP_089192582.1 arginine ABC transporter ATP-binding protein ArtP -
IHE77_RS08520 (IHE77_08510) 1772585..1773127 - 543 WP_033642535.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galU / wza / manB / galE / gnd / msbA / nueA 1481804..1843259 361455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.91 Da        Isoelectric Point: 10.6941

>T194228 WP_033633469.1 NZ_CP070508:c1768157-1767873 [Serratia ureilytica]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T194228 NZ_CP093391:4214400-4215329 [Salmonella enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTCAGGCTATTAATGACCGCCCTGCCGCATGTAGCAAAGGAGTCCTGCTT
CGCCCTGAAAGGCGGCACGGCAATAAATTTGTTTGTGCAGGATTTCCCTCGCCTCTCGGTAGATATCGATCTGGCGTACA
AGACCTATGCGGATCGCGATACCGATCTGGCTGCCATCAATGACGCCTTAATGCGCATTACGGAATCGCTGAACGACAGA
CCGGGGATCAGTGCTATCCGACAGGAGAATAAAGCGGATGAAAAGCGCATCATCGTCAACACCGCTGACGCGAAGATAAA
GATTGAGGTTAGTCCGGTCTGGCGTGGACTACTATTACCACCAACAGAAATGCCGGTATGTGAACAGGTGGAAATTGAAT
ATGGCTTCACCACCATGAATGTCGTCTCGCTGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTGCTGAATATGCTGGAAAAGCCGGGCCTGACGCGTGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGGCATCCCCGCCCCATTACCGAGCTGCTGGCACCAAACTGGGATACAGCGCGGATCACTACCCTGTACGCAC
AGGAATTTTCAGGCATGACACAGCAGGAAACATCGCTGGAATCCCTTTTATCAGTAACGACTTTGCTGCCACAAGCGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCCGCTATAAGCAAAATACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCAGCGATTCGCTGGAAGTCGCGTAACCTGGCGGTGCTGAAGGATAAGAATCCGGCCAAGT
ATGCGGCGGCGGTGAATAAGCTGGAGAGAGTTCTGGAGCAGTACCTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT194228 WP_004928423.1 NZ_CP070508:c1768398-1768147 [Serratia ureilytica]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT194228 NZ_CP093391:4213631-4214413 [Salmonella enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAGAACACCCTCCCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGTAATGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCGCACGGCGTATACTGCCGGACGG
GCCGTGAACCAGACTGGGTGGACGCAGTTTACTGCCTGCAAACGCAGTGGGAAAAGCCAGTTCGCATGGCCGGGCTGACC
AGCCTTGCGCTACAGGGCTATGCCCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTGGCACTTCCGGCTTACGCCAA
ACTGCCGGGATGGTTTGTCGCCTTTGAGCAATCCGCGATGTTTGTCACACTGTATACCTCTGGTCTCACCGTCGATATAA
CACCATTCACGACAAAACTGAATATCGGCGACCGGCAGTTAATAGGCAGTGTCCCAGAACTGGCCGCGTATGAGATCGCC
TGCGGAGTACCCTCGTTGATCTCATTCGAACATGCCGACGCTCTGTTTCAGGGAATGAATCTTCTCAGCCCGCGAAAATT
ACAGGCTTTGCTCTGCGCCAGCCATTCAGTTAAAACCAACCGGGTGATGCTCTATCTTGCCCGACGCAACGAGCACCCTT
ACTTTCAGTACCTCGATCAAAGCGGTATAGAAACAGGCACTGGAAAACGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GJ35

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References