Detailed information of TA system TA194226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 209385..209860
• Replicon: chromosome
• Accession: NZ_CP070508
• Organism: Serratia ureilytica strain AM923

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8B4GM79
• Locus tag: IHE77_RS00930
• Protein ID: WP_033645001.1
• Coordinates: 209585..209860 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IHE77_RS00925
• Protein ID: WP_223524348.1
• Coordinates: 209385..209585 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHE77_RS00895 (IHE77_00895)	204579..205847	+	1269	WP_033645006.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
IHE77_RS00900 (IHE77_00900)	205844..207043	+	1200	WP_033652425.1	anaerobic glycerol-3-phosphate dehydrogenase subunit GlpC	-
IHE77_RS00905 (IHE77_00905)	207078..207641	-	564	WP_046688053.1	DcrB family lipoprotein	-
IHE77_RS00910 (IHE77_00910)	207722..208156	-	435	WP_046688054.1	GNAT family N-acetyltransferase	-
IHE77_RS00915 (IHE77_00915)	208198..208857	-	660	WP_025304889.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
IHE77_RS00920 (IHE77_00920)	209078..209323	+	246	WP_025304890.1	sulfurtransferase TusA	-
IHE77_RS00925 (IHE77_00925)	209385..209585	+	201	WP_223524348.1	stability determinant	Antitoxin
IHE77_RS00930 (IHE77_00930)	209585..209860	+	276	WP_033645001.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
IHE77_RS00935 (IHE77_00935)	209920..212238	-	2319	WP_241440314.1	zinc/cadmium/mercury/lead-transporting ATPase	-
IHE77_RS00940 (IHE77_00940)	212919..214382	+	1464	WP_033644999.1	serralysin family metalloprotease	-
IHE77_RS00945 (IHE77_00945)	214437..214814	+	378	WP_025304893.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10682.57 Da
• Isoelectric Point: 11.2806

>T194226 WP_033645001.1 NZ_CP070508:209585-209860 [Serratia ureilytica]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVTPAARHPRIFRRGRVDGTHEIPLHPHYLLIYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T194226 NZ_CP093391:c4040622-4040314 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7526.59 Da
• Isoelectric Point: 4.1359

>AT194226 WP_223524348.1 NZ_CP070508:209385-209585 [Serratia ureilytica]
MMSILLLPTVAKMENEEHTQGYERWFLERVQEAMDEPWPGIPHDDVMAEMDAVIAAAEARINAKQA

Nucleotide

• Length: 201 bp

>AT194226 NZ_CP093391:c4040864-4040625 [Salmonella enterica]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: A0A8B4GM79