Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14143..14744 Replicon chromosome
Accession NZ_CP070508
Organism Serratia ureilytica strain AM923

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag IHE77_RS00065 Protein ID WP_025304766.1
Coordinates 14143..14523 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag IHE77_RS00070 Protein ID WP_025304767.1
Coordinates 14523..14744 (-) Length 74 a.a.

Genomic Context

IHE77_RS00040IHE77_RS00050IHE77_RS00055IHE77_RS00060IHE77_RS00080IHE77_RS00085IHE77_RS00045IHE77_RS00065IHE77_RS00070IHE77_RS00075
Location: 9390..10670 (1281 bp)
Type: Others
Protein ID: WP_103101713.1
Location: 11358..11771 (414 bp)
Type: Others
Protein ID: WP_004933919.1
Location: 11878..12306 (429 bp)
Type: Others
Protein ID: WP_004933922.1
Location: 12474..14132 (1659 bp)
Type: Others
Protein ID: WP_042783386.1
Location: 17096..17875 (780 bp)
Type: Others
Protein ID: WP_033645137.1
Location: 17955..19094 (1140 bp)
Type: Others
Protein ID: WP_033645136.1
Location: 10701..11048 (348 bp)
Type: Others
Protein ID: WP_016929593.1
Location: 14143..14523 (381 bp)
Type: Toxin
Protein ID: WP_025304766.1
Location: 14523..14744 (222 bp)
Type: Antitoxin
Protein ID: WP_025304767.1
Location: 14818..16068 (1251 bp)
Type: Others
Protein ID: WP_241440279.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IHE77_RS00040 (IHE77_00040)9390..10670+1281WP_103101713.1DUF3748 domain-containing protein-
IHE77_RS00045 (IHE77_00045)10701..11048-348WP_016929593.1YceK/YidQ family lipoprotein-
IHE77_RS00050 (IHE77_00050)11358..11771+414WP_004933919.1small heat shock chaperone IbpA-
IHE77_RS00055 (IHE77_00055)11878..12306+429WP_004933922.1small heat shock chaperone IbpB-
IHE77_RS00060 (IHE77_00060)12474..14132+1659WP_042783386.1putative transporter-
IHE77_RS00065 (IHE77_00065)14143..14523-381WP_025304766.1type II toxin-antitoxin system VapC family toxinToxin
IHE77_RS00070 (IHE77_00070)14523..14744-222WP_025304767.1ribbon-helix-helix domain-containing proteinAntitoxin
IHE77_RS00075 (IHE77_00075)14818..16068-1251WP_241440279.1valine--pyruvate transaminase-
IHE77_RS00080 (IHE77_00080)17096..17875+780WP_033645137.12OG-Fe dioxygenase family protein-
IHE77_RS00085 (IHE77_00085)17955..19094+1140WP_033645136.1PLP-dependent aspartate aminotransferase family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T194224 WP_025304766.1 NZ_CP070508:c14523-14143 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T194224 NZ_CP093391:c2122037-2121759 [Salmonella enterica]
ATGATTAAAAGCTTCAGACATAAGGGACTGAAAAAGTTCTATCAAAAAGGCGACAGCAGCGGTTTAGAACAATCACTGGT
CCCGCGCCTGAAAAACAGGTTATCCATGCTGGATGCAGCAAAGACAATTGATTTCCTGAATCAGCAAGGCTACGACCTTC
ATGAGCTTAAAGGCGATCGTGCTGAAACGTGGTCCATAAAAGTTTCTGGTAACTGGCGTCTGACGTTTATCTTTGAAAAC
GGTGACGTCTACGTTCTCAACCTGGAGGATTATCACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT194224 WP_025304767.1 NZ_CP070508:c14744-14523 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT194224 NZ_CP093391:c2121759-2121475 [Salmonella enterica]
ATGGCTATGTTCGATCCTGCTTACCCTGGCGAAATCATTGCCGAAATTCTGGAAGACCAGGGCGTAAGCCTGCGTCAGTT
TGCTGTAGCTATGAATATTGCGCCATCAACCGCCAGCCGTATTCTGAGCGGTAAAGTAAGTATCACGCCAGAAATGGCGG
TTAAGCTGGCTATCGTTCTTGGCGGCGATGCCGAAAGCTGGCTTAACCTTCAGAATAACTACAGTCTGTCGCAGGCACGT
AAAACAGTGGATATAACTCATGTTCACCGTCTGTCTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A8B4GSJ7

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A8B4GSF3

References