Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14143..14744 Replicon chromosome
Accession NZ_CP070508
Organism Serratia ureilytica strain AM923

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag IHE77_RS00065 Protein ID WP_025304766.1
Coordinates 14143..14523 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag IHE77_RS00070 Protein ID WP_025304767.1
Coordinates 14523..14744 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHE77_RS00040 (IHE77_00040) 9390..10670 + 1281 WP_103101713.1 DUF3748 domain-containing protein -
IHE77_RS00045 (IHE77_00045) 10701..11048 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
IHE77_RS00050 (IHE77_00050) 11358..11771 + 414 WP_004933919.1 small heat shock chaperone IbpA -
IHE77_RS00055 (IHE77_00055) 11878..12306 + 429 WP_004933922.1 small heat shock chaperone IbpB -
IHE77_RS00060 (IHE77_00060) 12474..14132 + 1659 WP_042783386.1 putative transporter -
IHE77_RS00065 (IHE77_00065) 14143..14523 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
IHE77_RS00070 (IHE77_00070) 14523..14744 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
IHE77_RS00075 (IHE77_00075) 14818..16068 - 1251 WP_241440279.1 valine--pyruvate transaminase -
IHE77_RS00080 (IHE77_00080) 17096..17875 + 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
IHE77_RS00085 (IHE77_00085) 17955..19094 + 1140 WP_033645136.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T194224 WP_025304766.1 NZ_CP070508:c14523-14143 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T194224 NZ_CP093391:c2122037-2121759 [Salmonella enterica]
ATGATTAAAAGCTTCAGACATAAGGGACTGAAAAAGTTCTATCAAAAAGGCGACAGCAGCGGTTTAGAACAATCACTGGT
CCCGCGCCTGAAAAACAGGTTATCCATGCTGGATGCAGCAAAGACAATTGATTTCCTGAATCAGCAAGGCTACGACCTTC
ATGAGCTTAAAGGCGATCGTGCTGAAACGTGGTCCATAAAAGTTTCTGGTAACTGGCGTCTGACGTTTATCTTTGAAAAC
GGTGACGTCTACGTTCTCAACCTGGAGGATTATCACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT194224 WP_025304767.1 NZ_CP070508:c14744-14523 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT194224 NZ_CP093391:c2121759-2121475 [Salmonella enterica]
ATGGCTATGTTCGATCCTGCTTACCCTGGCGAAATCATTGCCGAAATTCTGGAAGACCAGGGCGTAAGCCTGCGTCAGTT
TGCTGTAGCTATGAATATTGCGCCATCAACCGCCAGCCGTATTCTGAGCGGTAAAGTAAGTATCACGCCAGAAATGGCGG
TTAAGCTGGCTATCGTTCTTGGCGGCGATGCCGAAAGCTGGCTTAACCTTCAGAATAACTACAGTCTGTCGCAGGCACGT
AAAACAGTGGATATAACTCATGTTCACCGTCTGTCTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References