194223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 93316..94009 Replicon plasmid pSDM007
Accession NZ_CP070507
Organism Pseudomonas sp. SDM007

Toxin (Protein)


Gene name tad Uniprot ID A0A0D9A9G0
Locus tag JTY93_RS27975 Protein ID WP_042933781.1
Coordinates 93316..93693 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag JTY93_RS27980 Protein ID WP_001172026.1
Coordinates 93674..94009 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY93_RS27955 89146..89748 - 603 Protein_105 autotransporter assembly complex protein TamA -
JTY93_RS27960 89801..90505 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
JTY93_RS27965 90571..92538 - 1968 Protein_107 Tn3 family transposase -
JTY93_RS27970 92522..93124 - 603 WP_010465829.1 recombinase family protein -
JTY93_RS27975 93316..93693 + 378 WP_042933781.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JTY93_RS27980 93674..94009 + 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
JTY93_RS27985 94024..94359 + 336 WP_000741275.1 hypothetical protein -
JTY93_RS27990 94383..94709 + 327 WP_000091614.1 hypothetical protein -
JTY93_RS27995 94706..95086 + 381 WP_001054412.1 hypothetical protein -
JTY93_RS28000 95204..95545 + 342 WP_205519058.1 DUF3391 domain-containing protein -
JTY93_RS28005 95584..96498 + 915 WP_001736514.1 HD domain-containing protein -
JTY93_RS28010 96665..98023 - 1359 Protein_116 IS66 family transposase -
JTY93_RS28015 98074..98409 - 336 WP_076965119.1 IS66 family insertion sequence element accessory protein TnpB -
JTY93_RS28020 98406..98723 - 318 WP_076965118.1 IS66 family insertion sequence hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib - 1..249868 249868
- inside IScluster/Tn - - 89801..98723 8922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13735.81 Da        Isoelectric Point: 9.4693

>T194223 WP_042933781.1 NZ_CP070507:93316-93693 [Pseudomonas sp. SDM007]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGTGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T194223 NZ_CP093391:2074102-2074205 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT194223 WP_001172026.1 NZ_CP070507:93674-94009 [Pseudomonas sp. SDM007]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT194223 NZ_CP093391:c2074207-2074064 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D9A9G0

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References