Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 14069..14600 Replicon plasmid pSDM007
Accession NZ_CP070507
Organism Pseudomonas sp. SDM007

Toxin (Protein)


Gene name relE Uniprot ID W2D823
Locus tag JTY93_RS27520 Protein ID WP_011282522.1
Coordinates 14319..14600 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID W2D9V6
Locus tag JTY93_RS27515 Protein ID WP_020303033.1
Coordinates 14069..14332 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTY93_RS27485 9533..10279 - 747 WP_024015048.1 AraC family transcriptional regulator -
JTY93_RS27490 10279..10788 - 510 WP_003452327.1 lipoprotein signal peptidase -
JTY93_RS27495 10785..11132 - 348 WP_024015047.1 DUF3703 domain-containing protein -
JTY93_RS27505 12497..12904 - 408 WP_024015046.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
JTY93_RS27510 13002..13898 + 897 WP_085986662.1 cation diffusion facilitator family transporter -
JTY93_RS27515 14069..14332 + 264 WP_020303033.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JTY93_RS27520 14319..14600 + 282 WP_011282522.1 type II toxin-antitoxin system YafQ family toxin Toxin
JTY93_RS27525 14636..14820 + 185 Protein_19 hypothetical protein -
JTY93_RS27530 14820..15067 + 248 Protein_20 hypothetical protein -
JTY93_RS27535 15157..16782 - 1626 WP_205478543.1 HAMP domain-containing protein -
JTY93_RS27540 17836..18009 + 174 Protein_22 transposase -
JTY93_RS27545 18006..19223 + 1218 WP_003465063.1 TniQ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib - 1..249868 249868
- flank IS/Tn - - 19284..19898 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10710.20 Da        Isoelectric Point: 9.6866

>T194221 WP_011282522.1 NZ_CP070507:14319-14600 [Pseudomonas sp. SDM007]
MRTIEQTSRFKRDYKREAKGPHRQTLASDFIAVVTALANNQPLAEKHRDHALTGDWKDHRDCHIKPDLVLIYRKPDDAVL
QLVRLGSHSELGL

Download         Length: 282 bp

>T194221 NZ_CP093391:798060-798458 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACGTCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9471.95 Da        Isoelectric Point: 4.8096

>AT194221 WP_020303033.1 NZ_CP070507:14069-14332 [Pseudomonas sp. SDM007]
MSANAVVRARIDEHIKEEATVVLAAMGLTVSDAFRIMLTRVAREKALPFEPLIPNATTIEAMKEARRGGLKSFASVEDLM
ADLNADD

Download         Length: 264 bp

>AT194221 NZ_CP093391:797833-798060 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCGGTCAGATTGCCTAAATCAATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGTG
AAGATGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N2T9

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0N2R7

References