Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
Location | 14069..14600 | Replicon | plasmid pSDM007 |
Accession | NZ_CP070507 | ||
Organism | Pseudomonas sp. SDM007 |
Toxin (Protein)
Gene name | relE | Uniprot ID | W2D823 |
Locus tag | JTY93_RS27520 | Protein ID | WP_011282522.1 |
Coordinates | 14319..14600 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | W2D9V6 |
Locus tag | JTY93_RS27515 | Protein ID | WP_020303033.1 |
Coordinates | 14069..14332 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JTY93_RS27485 | 9533..10279 | - | 747 | WP_024015048.1 | AraC family transcriptional regulator | - |
JTY93_RS27490 | 10279..10788 | - | 510 | WP_003452327.1 | lipoprotein signal peptidase | - |
JTY93_RS27495 | 10785..11132 | - | 348 | WP_024015047.1 | DUF3703 domain-containing protein | - |
JTY93_RS27505 | 12497..12904 | - | 408 | WP_024015046.1 | Cd(II)/Pb(II)-responsive transcriptional regulator | - |
JTY93_RS27510 | 13002..13898 | + | 897 | WP_085986662.1 | cation diffusion facilitator family transporter | - |
JTY93_RS27515 | 14069..14332 | + | 264 | WP_020303033.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
JTY93_RS27520 | 14319..14600 | + | 282 | WP_011282522.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
JTY93_RS27525 | 14636..14820 | + | 185 | Protein_19 | hypothetical protein | - |
JTY93_RS27530 | 14820..15067 | + | 248 | Protein_20 | hypothetical protein | - |
JTY93_RS27535 | 15157..16782 | - | 1626 | WP_205478543.1 | HAMP domain-containing protein | - |
JTY93_RS27540 | 17836..18009 | + | 174 | Protein_22 | transposase | - |
JTY93_RS27545 | 18006..19223 | + | 1218 | WP_003465063.1 | TniQ family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aph(6)-Id / aph(3'')-Ib | - | 1..249868 | 249868 | |
- | flank | IS/Tn | - | - | 19284..19898 | 614 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10710.20 Da Isoelectric Point: 9.6866
>T194221 WP_011282522.1 NZ_CP070507:14319-14600 [Pseudomonas sp. SDM007]
MRTIEQTSRFKRDYKREAKGPHRQTLASDFIAVVTALANNQPLAEKHRDHALTGDWKDHRDCHIKPDLVLIYRKPDDAVL
QLVRLGSHSELGL
MRTIEQTSRFKRDYKREAKGPHRQTLASDFIAVVTALANNQPLAEKHRDHALTGDWKDHRDCHIKPDLVLIYRKPDDAVL
QLVRLGSHSELGL
Download Length: 282 bp
>T194221 NZ_CP093391:798060-798458 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACGTCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACGTCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9471.95 Da Isoelectric Point: 4.8096
>AT194221 WP_020303033.1 NZ_CP070507:14069-14332 [Pseudomonas sp. SDM007]
MSANAVVRARIDEHIKEEATVVLAAMGLTVSDAFRIMLTRVAREKALPFEPLIPNATTIEAMKEARRGGLKSFASVEDLM
ADLNADD
MSANAVVRARIDEHIKEEATVVLAAMGLTVSDAFRIMLTRVAREKALPFEPLIPNATTIEAMKEARRGGLKSFASVEDLM
ADLNADD
Download Length: 264 bp
>AT194221 NZ_CP093391:797833-798060 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCGGTCAGATTGCCTAAATCAATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGTG
AAGATGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCGGTCAGATTGCCTAAATCAATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGTG
AAGATGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0W0N2T9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0W0N2R7 |