Detailed information of TA system TA194220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 5973189..5974738
• Replicon: chromosome
• Accession: NZ_CP070506
• Organism: Pseudomonas sp. SDM007

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JTY93_RS27125
• Protein ID: WP_205476423.1
• Coordinates: 5973464..5974738 (-)
• Length: 425 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1S1UPJ9
• Locus tag: JTY93_RS27120
• Protein ID: WP_029290025.1
• Coordinates: 5973189..5973467 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY93_RS27090	5968665..5969312	+	648	WP_205476387.1	FMN-binding negative transcriptional regulator	-
JTY93_RS27095	5969299..5969745	+	447	WP_205476388.1	GNAT family N-acetyltransferase	-
JTY93_RS27100	5969756..5970427	+	672	WP_205476389.1	GNAT family N-acetyltransferase	-
JTY93_RS27105	5970529..5971428	-	900	WP_205476390.1	homocysteine S-methyltransferase family protein	-
JTY93_RS27110	5971540..5972358	+	819	WP_205476391.1	transporter substrate-binding domain-containing protein	-
JTY93_RS27115	5972355..5973185	+	831	WP_029290023.1	amino acid ABC transporter permease	-
JTY93_RS27120	5973189..5973467	-	279	WP_029290025.1	helix-turn-helix domain-containing protein	Antitoxin
JTY93_RS27125	5973464..5974738	-	1275	WP_205476423.1	HipA domain-containing protein	Toxin
JTY93_RS27130	5975080..5976348	+	1269	WP_205476392.1	autotransporter domain-containing protein	-
JTY93_RS27135	5976416..5978224	-	1809	WP_205476393.1	sodium-extruding oxaloacetate decarboxylase subunit alpha	-
JTY93_RS27140	5978236..5979651	-	1416	WP_029290035.1	acetyl-CoA carboxylase biotin carboxylase subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-351)

Antitoxin

• Cro/C1-type helix-turn-helix domain (27-80)

Sequences

Toxin

Protein

• Length: 425 a.a.
• Molecular weight: 46926.32 Da
• Isoelectric Point: 5.4395

>T194220 WP_205476423.1 NZ_CP070506:c5974738-5973464 [Pseudomonas sp. SDM007]
MRLEFSEPQIGFDGPCRFHYRQDYLVEHLGDIEQGFCSAVSGRFPLGWDVTFLKAAPAFLHDIAPAGAAKRFLMQRVGAD
KPDDVSVDLFLLGLCTPSPIGNLRIKESVEALGVRPAVGFSRHDVVSRDNGFLEYAYEQGEAIGGATGAGGEAPKLLMAE
NRDGRLYPDAVLPDAEVAQHWFIKFARNGATLNDQAILRSEFHYYKALQALGIETVAAQGLALEEAHKPSLWMQRFDRNV
TPAGVERLAVESIYSLAGVITPGSYMDHLEVVQMLAEHWRQVGQGHGVADLVAEYLRRDLLNKILGNSDNHGRNTSIIRE
RGSMRLAPIYDLAPMVMDTEGITRTTKWPRGLEVAGEIDWQGVCSALDGLVDPQQAFERLRADAEHLRALPDILVDSGLP
QETWKHPAIALGKLDQRLQQWGLR

Nucleotide

• Length: 1275 bp

>T194220 NZ_CP093391:788319-788732 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10197.95 Da
• Isoelectric Point: 11.9342

>AT194220 WP_029290025.1 NZ_CP070506:c5973467-5973189 [Pseudomonas sp. SDM007]
MTVSMDTRALLIQGIEQGLAQGTLQIGEAVRRLRVEVTGLHQSQFARMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGL
QMGVVRVRRSLG

Nucleotide

• Length: 279 bp

>AT194220 NZ_CP093391:788072-788338 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S1UPJ9