Detailed information of TA system TA194219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 5941458..5943166
• Replicon: chromosome
• Accession: NZ_CP070506
• Organism: Pseudomonas sp. SDM007

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: JTY93_RS26980
• Protein ID: WP_205478179.1
• Coordinates: 5941458..5942336 (+)
• Length: 293 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1S1UQA4
• Locus tag: JTY93_RS26985
• Protein ID: WP_029289973.1
• Coordinates: 5942333..5943166 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY93_RS26955	5937451..5938302	+	852	WP_205478182.1	ATP-binding cassette domain-containing protein	-
JTY93_RS26960	5938342..5939334	+	993	WP_205478181.1	ABC transporter substrate-binding protein	-
JTY93_RS26965	5939363..5940136	+	774	WP_029289965.1	ABC transporter permease	-
JTY93_RS26970	5940133..5940900	+	768	WP_205478180.1	SDR family oxidoreductase	-
JTY93_RS26975	5940914..5941453	+	540	WP_014720525.1	cupin domain-containing protein	-
JTY93_RS26980	5941458..5942336	+	879	WP_205478179.1	alpha/beta fold hydrolase	Toxin
JTY93_RS26985	5942333..5943166	+	834	WP_029289973.1	IclR family transcriptional regulator	Antitoxin
JTY93_RS26990	5943168..5943965	+	798	WP_205478178.1	SDR family oxidoreductase	-
JTY93_RS26995	5943958..5945640	+	1683	WP_205478177.1	thiamine pyrophosphate-binding protein	-
JTY93_RS27000	5945651..5946454	+	804	WP_205478176.1	aspartate dehydrogenase	-
JTY93_RS27005	5946465..5947958	+	1494	WP_205478175.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (45-276)

Antitoxin

• Transcription regulator IclR, C-terminal (136-256)

Sequences

Toxin

Protein

• Length: 293 a.a.
• Molecular weight: 30874.43 Da
• Isoelectric Point: 8.5063

>T194219 WP_205478179.1 NZ_CP070506:5941458-5942336 [Pseudomonas sp. SDM007]
MLPGLTQAAPTANLQAQLLRDFPQQRVASAGGQQALRECGTGPAVVLLHGIGSGAASWLQVAQHLAAQARVIAWDAPGYG
DSSPLESQVPKAEQYAARLVQMLDALQVDECVLVGHSLGALTALALARSAQAKRVSRLVLISPARGYGAPERSAQRQQVR
QQRLDNLQRLGIAGLAAQRSAHMLSPRAQPEALAWVHWNMARLNPLGYRQAIELLCGDDLLRHGQPAMPCDVHCGEADAI
TTPDTCLGVAKALGASFNLIADAGHASPIEQPLVVAGRLAYALKQSLTGRTL

Nucleotide

• Length: 879 bp

>T194219 NZ_CP093391:298512-298880 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30761.23 Da
• Isoelectric Point: 6.4976

>AT194219 WP_029289973.1 NZ_CP070506:5942333-5943166 [Pseudomonas sp. SDM007]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRVNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSHCTPKTVMELFDLLQADRQRGFVSGEGFFESAISTVAAPVRDQSGDIVAALGVTIPTTQIGHVNF
EELLTQVRRSADELSRLLNYNGGAHSGQPRVTALMRD

Nucleotide

• Length: 834 bp

>AT194219 NZ_CP093391:298294-298515 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1S1UQA4