Detailed information of TA system TA194216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2216605..2217218
• Replicon: chromosome
• Accession: NZ_CP070506
• Organism: Pseudomonas sp. SDM007

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JTY93_RS09900
• Protein ID: WP_169997548.1
• Coordinates: 2216967..2217218 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JTY93_RS09895
• Protein ID: WP_205478406.1
• Coordinates: 2216605..2216970 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY93_RS09875	2211847..2212998	+	1152	WP_205477785.1	efflux RND transporter periplasmic adaptor subunit	-
JTY93_RS09880	2212988..2214511	+	1524	WP_205477786.1	DHA2 family efflux MFS transporter permease subunit	-
JTY93_RS09885	2214704..2215288	-	585	WP_205478401.1	TetR family transcriptional regulator	-
JTY93_RS09890	2215431..2216603	+	1173	WP_205478404.1	MFS transporter	-
JTY93_RS09895	2216605..2216970	-	366	WP_205478406.1	toxin-antitoxin system HicB family antitoxin	Antitoxin
JTY93_RS09900	2216967..2217218	-	252	WP_169997548.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9422.02 Da
• Isoelectric Point: 9.6951

>T194216 WP_169997548.1 NZ_CP070506:c2217218-2216967 [Pseudomonas sp. SDM007]
VSKNEKLLAKLLNLQMAFTWPELITLLGWLGYRQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLESGG
LLQ

Nucleotide

• Length: 252 bp

>T194216 NZ_CP093390:c4520311-4519937 [Salmonella enterica]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACTTGTTTAGCGGTCGTATCGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCGAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13246.11 Da
• Isoelectric Point: 7.0381

>AT194216 WP_205478406.1 NZ_CP070506:c2216970-2216605 [Pseudomonas sp. SDM007]
MSNQLKHKGYIGSIEASVEDNCLFGKLLFIRALVSYEGQTVAQLEAAFREAVEDYLATCQTLGQAPEKPCKGSFNVRVGH
DLHLAAALAATQKKVTLNDLTRQALNEFLRHHATDIHPALG

Nucleotide

• Length: 366 bp

>AT194216 NZ_CP093390:c4520553-4520311 [Salmonella enterica]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAGGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA