Detailed information of TA system TA194215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1770860..1771476
• Replicon: chromosome
• Accession: NZ_CP070506
• Organism: Pseudomonas sp. SDM007

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S1UW78
• Locus tag: JTY93_RS07850
• Protein ID: WP_029292612.1
• Coordinates: 1770860..1771048 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JTY93_RS07855
• Protein ID: WP_205476967.1
• Coordinates: 1771072..1771476 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY93_RS07820	1765966..1766808	+	843	WP_205476962.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
JTY93_RS07825	1766769..1767578	+	810	WP_169956506.1	phosphonate C-P lyase system protein PhnK	-
JTY93_RS07830	1767575..1768297	+	723	WP_205476963.1	phosphonate C-P lyase system protein PhnL	-
JTY93_RS07835	1768287..1769432	+	1146	WP_205476964.1	alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase	-
JTY93_RS07840	1769432..1769998	+	567	WP_205476965.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-
JTY93_RS07845	1769989..1770738	+	750	WP_205476966.1	phosphonate metabolism protein PhnP	-
JTY93_RS07850	1770860..1771048	+	189	WP_029292612.1	type II toxin-antitoxin system HicA family toxin	Toxin
JTY93_RS07855	1771072..1771476	+	405	WP_205476967.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JTY93_RS07860	1771813..1773300	+	1488	Protein_1537	M10 family metallopeptidase	-
JTY93_RS07865	1773321..1774517	-	1197	WP_205476969.1	MFS transporter	-
JTY93_RS07870	1774747..1775751	-	1005	WP_169994372.1	sulfate ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7120.29 Da
• Isoelectric Point: 11.5133

>T194215 WP_029292612.1 NZ_CP070506:1770860-1771048 [Pseudomonas sp. SDM007]
VQSRLLIKELQAAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRQRAGLFSF

Nucleotide

• Length: 189 bp

>T194215 NZ_CP093390:c4227429-4226938 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14754.75 Da
• Isoelectric Point: 4.4787

>AT194215 WP_205476967.1 NZ_CP070506:1771072-1771476 [Pseudomonas sp. SDM007]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEMASEGRAIPMPTSVAAYHGNDEYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Nucleotide

• Length: 405 bp

>AT194215 NZ_CP093390:c4227719-4227426 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAGCGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A1S1UW78