Detailed information of TA system TA194214

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1480556..1481172
• Replicon: chromosome
• Accession: NZ_CP070506
• Organism: Pseudomonas sp. SDM007

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7Y1DDS6
• Locus tag: JTY93_RS06470
• Protein ID: WP_029299101.1
• Coordinates: 1480990..1481172 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JTY93_RS06465
• Protein ID: WP_169993613.1
• Coordinates: 1480556..1480966 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTY93_RS06445	1476948..1477574	-	627	WP_205478795.1	response regulator	-
JTY93_RS06450	1477716..1478861	-	1146	WP_205478800.1	EAL domain-containing protein	-
JTY93_RS06455	1479256..1479783	+	528	WP_205478793.1	DUF4142 domain-containing protein	-
JTY93_RS06460	1479953..1480432	-	480	WP_205478791.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
JTY93_RS06465	1480556..1480966	-	411	WP_169993613.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JTY93_RS06470	1480990..1481172	-	183	WP_029299101.1	type II toxin-antitoxin system HicA family toxin	Toxin
JTY93_RS06480	1481657..1482541	-	885	WP_205478789.1	alpha/beta hydrolase	-
JTY93_RS06485	1482841..1483533	-	693	WP_205478787.1	pseudouridine synthase	-
JTY93_RS06490	1483533..1483745	-	213	WP_205478785.1	cysteine-rich CWC family protein	-
JTY93_RS06495	1484380..1485492	-	1113	WP_205478799.1	enoyl-CoA hydratase/isomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6773.94 Da
• Isoelectric Point: 10.8600

>T194214 WP_029299101.1 NZ_CP070506:c1481172-1480990 [Pseudomonas sp. SDM007]
VDSRYLIGHIVADGWYLARVRGSHHHFKHPTKPGLVTIPHPRKELLDKTAKSILKQALLG

Nucleotide

• Length: 183 bp

>T194214 NZ_CP093390:4213206-4214135 [Salmonella enterica]
ATGGATCTGCGTGATAGTTATGCCCGACAGGTCAGGCTATTAATGACCGCCCTGCCGCATGTAGCAAAGGAGTCCTGCTT
CGCCCTGAAAGGCGGCACGGCAATAAATTTGTTTGTGCAGGATTTCCCTCGCCTCTCGGTAGATATCGATCTGGCGTACA
AGACCTATGCGGATCGCGATACCGATCTGGCTGCCATCAATGACGCCTTAATGCGCATTACGGAATCGCTGAACGACAGA
CCGGGGATCAGTGCTATCCGACAGGAGAATAAAGCGGATGAAAAGCGCATCATCGTCAACACCGCTGACGCGAAGATAAA
GATTGAGGTTAGTCCGGTCTGGCGTGGACTACTATTACCACCAACAGAAATGCCGGTATGTGAACAGGTGGAAATTGAAT
ATGGCTTCACCACCATGAATGTCGTCTCGCTGGCGGATCTTTACGGCGGTAAAATCTGCGCCGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGACGTGCTGAATATGCTGGAAAAGCCGGGCCTGACGCGTGAGATCTTTGACGGTTTTCTTTGCTA
TCTGGCAGGGCATCCCCGCCCCATTACCGAGCTGCTGGCACCAAACTGGGATACAGCGCGGATCACTACCCTGTACGCAC
AGGAATTTTCAGGCATGACACAGCAGGAAACATCGCTGGAATCCCTTTTATCAGTAACGACTTTGCTGCCACAAGCGCTG
AAATCGCATCTTACGGACAGAGATCGCCAGTTCTTGCTCCGCTATAAGCAAAATACCCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCAGCGATTCGCTGGAAGTCGCGTAACCTGGCGGTGCTGAAGGATAAGAATCCGGCCAAGT
ATGCGGCGGCGGTGAATAAGCTGGAGAGAGTTCTGGAGCAGTACCTTTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14825.80 Da
• Isoelectric Point: 4.5025

>AT194214 WP_169993613.1 NZ_CP070506:c1480966-1480556 [Pseudomonas sp. SDM007]
MLYPIAISTGDDDHAWGVEIPDIPGCFSAGDDLDDAMAMAREAIEGHFELLAEDGAPIPSAQKVTHHAANPLYAGCIWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQER

Nucleotide

• Length: 411 bp

>AT194214 NZ_CP093390:4212437-4213219 [Salmonella enterica]
TTGCCAAACTATCTAAACTGGCTGATGCAGAACACCCTCCCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGTAATGG
CATAGATCGTAAGCTTTCTTACCTCTATGTCCAGAATGGCTGGCTCAGGCGGATCGCGCACGGCGTATACTGCCGGACGG
GCCGTGAACCAGACTGGGTGGACGCAGTTTACTGCCTGCAAACGCAGTGGGAAAAGCCAGTTCGCATGGCCGGGCTGACC
AGCCTTGCGCTACAGGGCTATGCCCACTATACCGAACCGGGCAGGCCGCAGGTCTGGCTGGCACTTCCGGCTTACGCCAA
ACTGCCGGGATGGTTTGTCGCCTTTGAGCAATCCGCGATGTTTGTCACACTGTATACCTCTGGTCTCACCGTCGATATAA
CACCATTCACGACAAAACTGAATATCGGCGACCGGCAGTTAATAGGCAGTGTCCCAGAACTGGCCGCGTATGAGATCGCC
TGCGGAGTACCCTCGTTGATCTCATTCGAACATGCCGACGCTCTGTTTCAGGGAATGAATCTTCTCAGCCCGCGAAAATT
ACAGGCTTTGCTCTGCGCCAGCCATTCAGTTAAAACCAACCGGGTGATGCTCTATCTTGCCCGACGCAACGAGCACCCTT
ACTTTCAGTACCTCGATCAAAGCGGTATAGAAACAGGCACTGGAAAACGGCAAATCGTTCCCGGCGGCTGGCTGGAGCCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Structures

Toxin

• AlphaFold DB: A0A7Y1DDS6