Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 5566291..5566922 Replicon chromosome
Accession NZ_CP070503
Organism Pseudomonas atacamensis strain SM1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JWU58_RS25190 Protein ID WP_206421181.1
Coordinates 5566291..5566653 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J2YH56
Locus tag JWU58_RS25195 Protein ID WP_008077592.1
Coordinates 5566653..5566922 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWU58_RS25180 5561420..5564773 + 3354 WP_206421179.1 mechanosensitive channel MscK -
JWU58_RS25185 5564822..5566285 + 1464 WP_206421180.1 YdiU family protein -
JWU58_RS25190 5566291..5566653 - 363 WP_206421181.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JWU58_RS25195 5566653..5566922 - 270 WP_008077592.1 hypothetical protein Antitoxin
JWU58_RS25200 5567161..5567595 + 435 WP_206421182.1 thioredoxin TrxC -
JWU58_RS25205 5567725..5568495 - 771 WP_206421183.1 AAA family ATPase -
JWU58_RS25210 5568852..5569577 + 726 WP_206421184.1 beta-ketoacyl synthase chain length factor -
JWU58_RS25215 5569553..5570365 + 813 WP_016772024.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
JWU58_RS25220 5570343..5570618 + 276 WP_016772025.1 acyl carrier protein -
JWU58_RS25225 5570628..5570882 + 255 WP_016772026.1 acyl carrier protein -
JWU58_RS25230 5570879..5571424 + 546 WP_123444000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13381.33 Da        Isoelectric Point: 7.1674

>T194209 WP_206421181.1 NZ_CP070503:c5566653-5566291 [Pseudomonas atacamensis]
MVRRQPPQRGDVYWIDLNPVAGREMMNRHRFVVITPREINALGVSMTVPVTSGGNFSRNMGLVVAITGHETNGVAVCNQV
RSFDIEQRVRDGTAKFIERLDDVTMSDIVDRVISAIDPLS

Download         Length: 363 bp

>T194209 NZ_CP093390:2068692-2068795 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9521.94 Da        Isoelectric Point: 5.1069

>AT194209 WP_008077592.1 NZ_CP070503:c5566922-5566653 [Pseudomonas atacamensis]
MSVTSKIRRQGGAAVITIPPTLLKLLHLEVGAQLELNVVDGELIARPAVAATRKRYSLSELLEGAEELQKLNAQTSETLE
GDSVGRELG

Download         Length: 270 bp

>AT194209 NZ_CP093390:c2068797-2068654 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J2YH56

References