Detailed information of TA system TA194208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 5166886..5167475
• Replicon: chromosome
• Accession: NZ_CP070503
• Organism: Pseudomonas atacamensis strain SM1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JWU58_RS23580
• Protein ID: WP_081489836.1
• Coordinates: 5166886..5167137 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: V8R847
• Locus tag: JWU58_RS23585
• Protein ID: WP_016771749.1
• Coordinates: 5167134..5167475 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWU58_RS23560	5162226..5162786	-	561	WP_125927175.1	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	-
JWU58_RS23565	5162851..5165028	-	2178	WP_206421065.1	DUF1631 family protein	-
JWU58_RS23570	5165295..5166143	+	849	WP_016771747.1	carboxylating nicotinate-nucleotide diphosphorylase	-
JWU58_RS23575	5166231..5166530	-	300	WP_024011573.1	hypothetical protein	-
JWU58_RS23580	5166886..5167137	+	252	WP_081489836.1	type II toxin-antitoxin system HicA family toxin	Toxin
JWU58_RS23585	5167134..5167475	+	342	WP_016771749.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JWU58_RS23595	5167859..5169964	-	2106	WP_024011572.1	polyribonucleotide nucleotidyltransferase	-
JWU58_RS23600	5170169..5170438	-	270	WP_016771751.1	30S ribosomal protein S15	-
JWU58_RS23605	5170582..5171499	-	918	WP_024011571.1	tRNA pseudouridine(55) synthase TruB	-
JWU58_RS23610	5171504..5171905	-	402	WP_016771753.1	30S ribosome-binding factor RbfA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9174.63 Da
• Isoelectric Point: 10.7459

>T194208 WP_081489836.1 NZ_CP070503:5166886-5167137 [Pseudomonas atacamensis]
MSKTEKLLAKLVNGRSAFTWSELVTLLARLGYSQLEGSGSRIKFDNGNPSALINLHKPHPGNEIKTYARRQIIEQLKTGG
LIP

Nucleotide

• Length: 252 bp

>T194208 NZ_CP093390:c943154-942627 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACAAAAACCTACGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACCGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTTTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12594.21 Da
• Isoelectric Point: 5.9655

>AT194208 WP_016771749.1 NZ_CP070503:5167134-5167475 [Pseudomonas atacamensis]
MSSQLHYKGYVGSIEASTEDKCLFGKLLFIRALVNYEGQTVAELEAAFREAVDDYLQTCEQLGQKPEIPCKGSFNVRIGH
DLHLAAALAATRQNVSLNDLTRQALNEYLQHHA

Nucleotide

• Length: 342 bp

>AT194208 NZ_CP093390:c943441-943151 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGTGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: V8R847