Detailed information of TA system TA194206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3326804..3327323
• Replicon: chromosome
• Accession: NZ_CP070503
• Organism: Pseudomonas atacamensis strain SM1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JWU58_RS15070
• Protein ID: WP_197890164.1
• Coordinates: 3326804..3327085 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N6YEG7
• Locus tag: JWU58_RS15075
• Protein ID: WP_039758605.1
• Coordinates: 3327075..3327323 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWU58_RS15040	3322157..3322921	-	765	WP_016774498.1	IclR family transcriptional regulator	-
JWU58_RS15045	3323080..3323469	-	390	WP_016774497.1	RidA family protein	-
JWU58_RS15050	3323501..3324292	-	792	WP_016774496.1	amino acid ABC transporter ATP-binding protein	-
JWU58_RS15055	3324289..3324951	-	663	WP_071172258.1	amino acid ABC transporter permease	-
JWU58_RS15060	3324961..3325623	-	663	WP_024012746.1	amino acid ABC transporter permease	-
JWU58_RS15065	3325674..3326522	-	849	WP_016774493.1	transporter substrate-binding domain-containing protein	-
JWU58_RS15070	3326804..3327085	-	282	WP_197890164.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JWU58_RS15075	3327075..3327323	-	249	WP_039758605.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JWU58_RS15080	3327572..3328003	+	432	WP_125916105.1	thioredoxin family protein	-
JWU58_RS15085	3328119..3329195	+	1077	WP_206420426.1	diguanylate cyclase	-
JWU58_RS15090	3329231..3330790	-	1560	WP_206420427.1	CBS domain-containing protein	-
JWU58_RS15095	3331148..3331897	-	750	WP_206420429.1	VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10878.70 Da
• Isoelectric Point: 10.6803

>T194206 WP_197890164.1 NZ_CP070503:c3327085-3326804 [Pseudomonas atacamensis]
MTYELEFSEKAWKEWRKLGSELREQFKNKLVERLANPHVPAARLKGLCNAYKIKLRSAGYRLVYRVRDEVLVVTVIAVGK
RQGGDVYRQALNR

Nucleotide

• Length: 282 bp

>T194206 NZ_CP093390:788437-788850 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9043.47 Da
• Isoelectric Point: 4.7905

>AT194206 WP_039758605.1 NZ_CP070503:c3327323-3327075 [Pseudomonas atacamensis]
MTHIVLSHVVASISELKKNPMGTVAAGGGRSVAILNRNEPAFYCVPAKEYEAMMERLEDLELIALCKERENDPTIKVSID
DL

Nucleotide

• Length: 249 bp

>AT194206 NZ_CP093390:788190-788456 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1N6YEG7