Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1589414..1590069 Replicon chromosome
Accession NZ_CP070501
Organism Agrococcus sp. Marseille-Q4369

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JSQ78_RS07955 Protein ID WP_026373128.1
Coordinates 1589414..1589851 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JSQ78_RS07960 Protein ID WP_211446872.1
Coordinates 1589848..1590069 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ78_RS07945 (JSQ78_07945) 1587142..1587873 - 732 WP_211446868.1 DUF4194 domain-containing protein -
JSQ78_RS07950 (JSQ78_07950) 1587870..1589324 - 1455 WP_211446870.1 DUF3375 domain-containing protein -
JSQ78_RS07955 (JSQ78_07955) 1589414..1589851 - 438 WP_026373128.1 type II toxin-antitoxin system VapC family toxin Toxin
JSQ78_RS07960 (JSQ78_07960) 1589848..1590069 - 222 WP_211446872.1 hypothetical protein Antitoxin
JSQ78_RS07965 (JSQ78_07965) 1590154..1590855 + 702 WP_211446873.1 FCD domain-containing protein -
JSQ78_RS07970 (JSQ78_07970) 1590980..1592311 + 1332 WP_211446875.1 MFS transporter -
JSQ78_RS07975 (JSQ78_07975) 1592359..1593618 + 1260 WP_211446876.1 alpha-hydroxy acid oxidase -
JSQ78_RS13840 1593740..1593952 + 213 Protein_1575 nuclease -
JSQ78_RS07985 (JSQ78_07985) 1594022..1594603 - 582 WP_211446878.1 cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15173.26 Da        Isoelectric Point: 6.3288

>T194200 WP_026373128.1 NZ_CP070501:c1589851-1589414 [Agrococcus sp. Marseille-Q4369]
VILLDTSVLVYAVGAEHPLREPCRAVIAAVGDGTLAATTTVEVLQEFAHVRARRRGRDDAAALTERYATALAPLISVDAD
DLSAGLRLFREHEPLGAFDAVLAAVAQRRDHVRALVSADRGFASIPGLVHLDPGASGFRAAAGIG

Download         Length: 438 bp

>T194200 NZ_CP093386:c4659745-4659434 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7700.72 Da        Isoelectric Point: 4.5388

>AT194200 WP_211446872.1 NZ_CP070501:c1590069-1589848 [Agrococcus sp. Marseille-Q4369]
VLIETEQRVRLEQRAADRGVSVAALVRDAIDLVYPPHGDRRAAAAADILAAEPMAVGDPAALRAELDELRGGA

Download         Length: 222 bp

>AT194200 NZ_CP093386:c4659433-4659143 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References