Detailed information of TA system TA194200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1589414..1590069
• Replicon: chromosome
• Accession: NZ_CP070501
• Organism: Agrococcus sp. Marseille-Q4369

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JSQ78_RS07955
• Protein ID: WP_026373128.1
• Coordinates: 1589414..1589851 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JSQ78_RS07960
• Protein ID: WP_211446872.1
• Coordinates: 1589848..1590069 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ78_RS07945 (JSQ78_07945)	1587142..1587873	-	732	WP_211446868.1	DUF4194 domain-containing protein	-
JSQ78_RS07950 (JSQ78_07950)	1587870..1589324	-	1455	WP_211446870.1	DUF3375 domain-containing protein	-
JSQ78_RS07955 (JSQ78_07955)	1589414..1589851	-	438	WP_026373128.1	type II toxin-antitoxin system VapC family toxin	Toxin
JSQ78_RS07960 (JSQ78_07960)	1589848..1590069	-	222	WP_211446872.1	hypothetical protein	Antitoxin
JSQ78_RS07965 (JSQ78_07965)	1590154..1590855	+	702	WP_211446873.1	FCD domain-containing protein	-
JSQ78_RS07970 (JSQ78_07970)	1590980..1592311	+	1332	WP_211446875.1	MFS transporter	-
JSQ78_RS07975 (JSQ78_07975)	1592359..1593618	+	1260	WP_211446876.1	alpha-hydroxy acid oxidase	-
JSQ78_RS13840	1593740..1593952	+	213	Protein_1575	nuclease	-
JSQ78_RS07985 (JSQ78_07985)	1594022..1594603	-	582	WP_211446878.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15173.26 Da
• Isoelectric Point: 6.3288

>T194200 WP_026373128.1 NZ_CP070501:c1589851-1589414 [Agrococcus sp. Marseille-Q4369]
VILLDTSVLVYAVGAEHPLREPCRAVIAAVGDGTLAATTTVEVLQEFAHVRARRRGRDDAAALTERYATALAPLISVDAD
DLSAGLRLFREHEPLGAFDAVLAAVAQRRDHVRALVSADRGFASIPGLVHLDPGASGFRAAAGIG

Nucleotide

• Length: 438 bp

>T194200 NZ_CP093386:c4659745-4659434 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 7700.72 Da
• Isoelectric Point: 4.5388

>AT194200 WP_211446872.1 NZ_CP070501:c1590069-1589848 [Agrococcus sp. Marseille-Q4369]
VLIETEQRVRLEQRAADRGVSVAALVRDAIDLVYPPHGDRRAAAAADILAAEPMAVGDPAALRAELDELRGGA

Nucleotide

• Length: 222 bp

>AT194200 NZ_CP093386:c4659433-4659143 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA