Detailed information of TA system TA194199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 283824..284419
• Replicon: chromosome
• Accession: NZ_CP070501
• Organism: Agrococcus sp. Marseille-Q4369

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JSQ78_RS01545
• Protein ID: WP_211448862.1
• Coordinates: 284027..284419 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JSQ78_RS01540
• Protein ID: WP_211448860.1
• Coordinates: 283824..284024 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ78_RS01520 (JSQ78_01520)	279792..281555	+	1764	WP_211448852.1	2-isopropylmalate synthase	-
JSQ78_RS01525 (JSQ78_01525)	281559..282290	+	732	WP_211448854.1	DNA repair protein RecO	-
JSQ78_RS01530 (JSQ78_01530)	282287..283066	+	780	WP_211448856.1	isoprenyl transferase	-
JSQ78_RS01535 (JSQ78_01535)	283191..283724	-	534	WP_211448858.1	hypothetical protein	-
JSQ78_RS01540 (JSQ78_01540)	283824..284024	+	201	WP_211448860.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JSQ78_RS01545 (JSQ78_01545)	284027..284419	+	393	WP_211448862.1	PIN domain nuclease	Toxin
JSQ78_RS01550 (JSQ78_01550)	284409..285041	-	633	WP_211448864.1	hypothetical protein	-
JSQ78_RS01555 (JSQ78_01555)	285231..286610	+	1380	WP_211448865.1	glycine--tRNA ligase	-
JSQ78_RS01560 (JSQ78_01560)	286607..287758	+	1152	WP_211448867.1	tRNA dihydrouridine synthase DusB	-
JSQ78_RS01565 (JSQ78_01565)	287748..288989	+	1242	WP_211448869.1	deoxyguanosinetriphosphate triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-37)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14386.59 Da
• Isoelectric Point: 7.1098

>T194199 WP_211448862.1 NZ_CP070501:284027-284419 [Agrococcus sp. Marseille-Q4369]
VLVDTSAWIEFLRATGSRAHVALRDALRDERRLVVCEPVQMEVLAGARSEQHVAELRGLLARCELVRTVPSDWDDAARIY
RTGRRQGVTIRKLVDCLIAAMAMRAGEPLLYAGADFDAIARVTDLDAVRG

Nucleotide

• Length: 393 bp

>T194199 NZ_CP093386:c4339282-4338791 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7185.03 Da
• Isoelectric Point: 4.3308

>AT194199 WP_211448860.1 NZ_CP070501:283824-284024 [Agrococcus sp. Marseille-Q4369]
MARTNIDLDESAVEAVMRRFSFTTKREAVNYALRALASEPLDVAGALALEGSGWDADLDELRASRA

Nucleotide

• Length: 201 bp

>AT194199 NZ_CP093386:c4339572-4339279 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA