Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 283824..284419 Replicon chromosome
Accession NZ_CP070501
Organism Agrococcus sp. Marseille-Q4369

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JSQ78_RS01545 Protein ID WP_211448862.1
Coordinates 284027..284419 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JSQ78_RS01540 Protein ID WP_211448860.1
Coordinates 283824..284024 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ78_RS01520 (JSQ78_01520) 279792..281555 + 1764 WP_211448852.1 2-isopropylmalate synthase -
JSQ78_RS01525 (JSQ78_01525) 281559..282290 + 732 WP_211448854.1 DNA repair protein RecO -
JSQ78_RS01530 (JSQ78_01530) 282287..283066 + 780 WP_211448856.1 isoprenyl transferase -
JSQ78_RS01535 (JSQ78_01535) 283191..283724 - 534 WP_211448858.1 hypothetical protein -
JSQ78_RS01540 (JSQ78_01540) 283824..284024 + 201 WP_211448860.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JSQ78_RS01545 (JSQ78_01545) 284027..284419 + 393 WP_211448862.1 PIN domain nuclease Toxin
JSQ78_RS01550 (JSQ78_01550) 284409..285041 - 633 WP_211448864.1 hypothetical protein -
JSQ78_RS01555 (JSQ78_01555) 285231..286610 + 1380 WP_211448865.1 glycine--tRNA ligase -
JSQ78_RS01560 (JSQ78_01560) 286607..287758 + 1152 WP_211448867.1 tRNA dihydrouridine synthase DusB -
JSQ78_RS01565 (JSQ78_01565) 287748..288989 + 1242 WP_211448869.1 deoxyguanosinetriphosphate triphosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-37)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14386.59 Da        Isoelectric Point: 7.1098

>T194199 WP_211448862.1 NZ_CP070501:284027-284419 [Agrococcus sp. Marseille-Q4369]
VLVDTSAWIEFLRATGSRAHVALRDALRDERRLVVCEPVQMEVLAGARSEQHVAELRGLLARCELVRTVPSDWDDAARIY
RTGRRQGVTIRKLVDCLIAAMAMRAGEPLLYAGADFDAIARVTDLDAVRG

Download         Length: 393 bp

>T194199 NZ_CP093386:c4339282-4338791 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7185.03 Da        Isoelectric Point: 4.3308

>AT194199 WP_211448860.1 NZ_CP070501:283824-284024 [Agrococcus sp. Marseille-Q4369]
MARTNIDLDESAVEAVMRRFSFTTKREAVNYALRALASEPLDVAGALALEGSGWDADLDELRASRA

Download         Length: 201 bp

>AT194199 NZ_CP093386:c4339572-4339279 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References