Detailed information of TA system TA194197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4788161..4788786
• Replicon: chromosome
• Accession: NZ_CP070499
• Organism: Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JQS43_RS21465
• Protein ID: WP_239676178.1
• Coordinates: 4788161..4788556 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQS43_RS21470
• Protein ID: WP_239676179.1
• Coordinates: 4788553..4788786 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQS43_RS21430 (JQS43_21350)	4783430..4784122	+	693	WP_239679594.1	hypothetical protein	-
JQS43_RS21435 (JQS43_21355)	4784251..4784472	+	222	WP_239676173.1	hypothetical protein	-
JQS43_RS21440 (JQS43_21360)	4784517..4785002	-	486	WP_239676174.1	hypothetical protein	-
JQS43_RS21445 (JQS43_21365)	4785166..4785591	+	426	WP_239676175.1	Fur family transcriptional regulator	-
JQS43_RS21450 (JQS43_21370)	4785614..4786483	+	870	WP_239679525.1	oxygenase MpaB family protein	-
JQS43_RS21455 (JQS43_21375)	4786514..4787335	+	822	WP_239676176.1	glutaminyl-peptide cyclotransferase	-
JQS43_RS21460 (JQS43_21380)	4787393..4788043	-	651	WP_239676177.1	formylglycine-generating enzyme family protein	-
JQS43_RS21465 (JQS43_21385)	4788161..4788556	-	396	WP_239676178.1	PIN domain-containing protein	Toxin
JQS43_RS21470 (JQS43_21390)	4788553..4788786	-	234	WP_239676179.1	hypothetical protein	Antitoxin
JQS43_RS21475 (JQS43_21395)	4789044..4789595	+	552	WP_239676180.1	DinB family protein	-
JQS43_RS21480 (JQS43_21400)	4789742..4790056	+	315	WP_239679526.1	MazG-like family protein	-
JQS43_RS21485 (JQS43_21405)	4790237..4790860	-	624	WP_239676181.1	class I SAM-dependent methyltransferase	-
JQS43_RS21490 (JQS43_21410)	4790965..4791930	-	966	WP_239676182.1	ion transporter	-
JQS43_RS21495 (JQS43_21415)	4792005..4792904	-	900	WP_239676183.1	PD-(D/E)XK nuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14462.45 Da
• Isoelectric Point: 6.7546

>T194197 WP_239676178.1 NZ_CP070499:c4788556-4788161 [Natronosporangium hydrolyticum]
VTSLLDANVLIALLNTDHVHHRAAQRWFVDLQESFATCPVTEGALARFAFRAGKAAEDVEQLIGMVAQHPRREFWPDSLP
YDRVAFKGVIGHRQVTDAYLAQLARANGGRLATFDKGLAQFHGDVAELIPV

Nucleotide

• Length: 396 bp

>T194197 NZ_CP093386:c4116480-4116193 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8448.44 Da
• Isoelectric Point: 4.2537

>AT194197 WP_239676179.1 NZ_CP070499:c4788786-4788553 [Natronosporangium hydrolyticum]
MRTTIDLPPDLHQQALAIARDTSRTLSETVADLMRRALGQGQPSDSPITRDELTGLPVFSVGKVITTEDVRSLEDDE

Nucleotide

• Length: 234 bp

>AT194197 NZ_CP093386:c4116206-4115904 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG