Detailed information of TA system TA194195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4523380..4523927
• Replicon: chromosome
• Accession: NZ_CP070499
• Organism: Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JQS43_RS20375
• Protein ID: WP_239675980.1
• Coordinates: 4523380..4523646 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JQS43_RS20380
• Protein ID: WP_239675981.1
• Coordinates: 4523643..4523927 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQS43_RS20350 (JQS43_20275)	4518503..4519309	+	807	WP_239675975.1	hypothetical protein	-
JQS43_RS20355 (JQS43_20280)	4519333..4521282	+	1950	WP_239675976.1	fumarate reductase/succinate dehydrogenase flavoprotein subunit	-
JQS43_RS20360 (JQS43_20285)	4521279..4522322	+	1044	WP_239675977.1	succinate dehydrogenase/fumarate reductase iron-sulfur subunit	-
JQS43_RS20365 (JQS43_20290)	4522417..4522839	-	423	WP_239675978.1	(deoxy)nucleoside triphosphate pyrophosphohydrolase	-
JQS43_RS20370 (JQS43_20295)	4523018..4523347	+	330	WP_239675979.1	4a-hydroxytetrahydrobiopterin dehydratase	-
JQS43_RS20375 (JQS43_20300)	4523380..4523646	-	267	WP_239675980.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JQS43_RS20380 (JQS43_20305)	4523643..4523927	-	285	WP_239675981.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JQS43_RS20385 (JQS43_20310)	4524000..4524734	+	735	WP_239675982.1	class I SAM-dependent methyltransferase	-
JQS43_RS20390 (JQS43_20315)	4525253..4526338	-	1086	WP_239675983.1	redox-regulated ATPase YchF	-
JQS43_RS20395 (JQS43_20320)	4526404..4526925	-	522	WP_239675984.1	hypothetical protein	-
JQS43_RS20400 (JQS43_20325)	4526925..4527215	-	291	WP_239675985.1	hypothetical protein	-
JQS43_RS20405 (JQS43_20330)	4527218..4527808	-	591	WP_239675986.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (35-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10353.96 Da
• Isoelectric Point: 10.9539

>T194195 WP_239675980.1 NZ_CP070499:c4523646-4523380 [Natronosporangium hydrolyticum]
VTYRIELTRAARRALVKDLPEVAAVACWEFIRGPLSEHPHRVGKALRDQLAGHYSARRGEFRVIYQIYEDRVVVRVVAIR
HRRDAYQR

Nucleotide

• Length: 267 bp

>T194195 NZ_CP093386:3516369-3516587 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10592.94 Da
• Isoelectric Point: 4.5317

>AT194195 WP_239675981.1 NZ_CP070499:c4523927-4523643 [Natronosporangium hydrolyticum]
MTTIPLAEARANLSRLVDEAVRTHERVEVTRKGRRAAVIMSADDYDSIMETLDILSDPELVREIRAATAEAEQGEVFSLE
EVTEEMRAHGRLPR

Nucleotide

• Length: 285 bp

>AT194195 NZ_CP093386:3515967-3516341 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA