Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4424683..4425253 Replicon chromosome
Accession NZ_CP070499
Organism Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JQS43_RS19855 Protein ID WP_239675885.1
Coordinates 4424683..4425030 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JQS43_RS19860 Protein ID WP_239675886.1
Coordinates 4425017..4425253 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQS43_RS19825 (JQS43_19750) 4419779..4421440 - 1662 WP_239675880.1 copper resistance protein CopC -
JQS43_RS19830 (JQS43_19755) 4421531..4422007 + 477 WP_239675881.1 thioredoxin-dependent thiol peroxidase -
JQS43_RS19840 (JQS43_19765) 4422174..4422995 - 822 WP_239675882.1 MOSC domain-containing protein -
JQS43_RS19845 (JQS43_19770) 4423079..4423906 + 828 WP_239675883.1 alpha/beta fold hydrolase -
JQS43_RS19850 (JQS43_19775) 4423903..4424619 - 717 WP_239675884.1 YoaK family protein -
JQS43_RS19855 (JQS43_19780) 4424683..4425030 - 348 WP_239675885.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JQS43_RS19860 (JQS43_19785) 4425017..4425253 - 237 WP_239675886.1 ribbon-helix-helix domain-containing protein Antitoxin
JQS43_RS19865 (JQS43_19790) 4425293..4426075 - 783 WP_239675887.1 class I SAM-dependent methyltransferase -
JQS43_RS19870 (JQS43_19795) 4426228..4427880 + 1653 WP_239675888.1 urocanate hydratase -
JQS43_RS19875 (JQS43_19800) 4427877..4429088 + 1212 WP_239675889.1 allantoate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12422.21 Da        Isoelectric Point: 11.2003

>T194194 WP_239675885.1 NZ_CP070499:c4425030-4424683 [Natronosporangium hydrolyticum]
MRRGEVYLVDLEPAQGAEANKVRPAVVVSNDAANRSAEQTGRGVVTVVPVTSNTGRVYPFQVLLRAADSGLREDSKAQAE
QVRSVAVRRIRQRVGGLPAPVLAELDRALRLHLAL

Download         Length: 348 bp

>T194194 NZ_CP093386:2459480-2459764 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8525.21 Da        Isoelectric Point: 4.1353

>AT194194 WP_239675886.1 NZ_CP070499:c4425253-4425017 [Natronosporangium hydrolyticum]
MKLSVSLPEADVAFLDDYATRAGGSSRSSVVQRAIRLLRTAELEEAYAHAYQEWEASEDAELWDRAAGDGDGYGDASR

Download         Length: 237 bp

>AT194194 NZ_CP093386:2459242-2459490 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References