Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 4424683..4425253 | Replicon | chromosome |
| Accession | NZ_CP070499 | ||
| Organism | Natronosporangium hydrolyticum strain DSM 106523 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | JQS43_RS19855 | Protein ID | WP_239675885.1 |
| Coordinates | 4424683..4425030 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | JQS43_RS19860 | Protein ID | WP_239675886.1 |
| Coordinates | 4425017..4425253 (-) | Length | 79 a.a. |
Genomic Context
Location: 4421531..4422007 (477 bp)
Type: Others
Protein ID: WP_239675881.1
Type: Others
Protein ID: WP_239675881.1
Location: 4423079..4423906 (828 bp)
Type: Others
Protein ID: WP_239675883.1
Type: Others
Protein ID: WP_239675883.1
Location: 4426228..4427880 (1653 bp)
Type: Others
Protein ID: WP_239675888.1
Type: Others
Protein ID: WP_239675888.1
Location: 4427877..4429088 (1212 bp)
Type: Others
Protein ID: WP_239675889.1
Type: Others
Protein ID: WP_239675889.1
Location: 4419779..4421440 (1662 bp)
Type: Others
Protein ID: WP_239675880.1
Type: Others
Protein ID: WP_239675880.1
Location: 4422174..4422995 (822 bp)
Type: Others
Protein ID: WP_239675882.1
Type: Others
Protein ID: WP_239675882.1
Location: 4423903..4424619 (717 bp)
Type: Others
Protein ID: WP_239675884.1
Type: Others
Protein ID: WP_239675884.1
Location: 4424683..4425030 (348 bp)
Type: Toxin
Protein ID: WP_239675885.1
Type: Toxin
Protein ID: WP_239675885.1
Location: 4425017..4425253 (237 bp)
Type: Antitoxin
Protein ID: WP_239675886.1
Type: Antitoxin
Protein ID: WP_239675886.1
Location: 4425293..4426075 (783 bp)
Type: Others
Protein ID: WP_239675887.1
Type: Others
Protein ID: WP_239675887.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JQS43_RS19825 (JQS43_19750) | 4419779..4421440 | - | 1662 | WP_239675880.1 | copper resistance protein CopC | - |
| JQS43_RS19830 (JQS43_19755) | 4421531..4422007 | + | 477 | WP_239675881.1 | thioredoxin-dependent thiol peroxidase | - |
| JQS43_RS19840 (JQS43_19765) | 4422174..4422995 | - | 822 | WP_239675882.1 | MOSC domain-containing protein | - |
| JQS43_RS19845 (JQS43_19770) | 4423079..4423906 | + | 828 | WP_239675883.1 | alpha/beta fold hydrolase | - |
| JQS43_RS19850 (JQS43_19775) | 4423903..4424619 | - | 717 | WP_239675884.1 | YoaK family protein | - |
| JQS43_RS19855 (JQS43_19780) | 4424683..4425030 | - | 348 | WP_239675885.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| JQS43_RS19860 (JQS43_19785) | 4425017..4425253 | - | 237 | WP_239675886.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| JQS43_RS19865 (JQS43_19790) | 4425293..4426075 | - | 783 | WP_239675887.1 | class I SAM-dependent methyltransferase | - |
| JQS43_RS19870 (JQS43_19795) | 4426228..4427880 | + | 1653 | WP_239675888.1 | urocanate hydratase | - |
| JQS43_RS19875 (JQS43_19800) | 4427877..4429088 | + | 1212 | WP_239675889.1 | allantoate amidohydrolase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12422.21 Da Isoelectric Point: 11.2003
>T194194 WP_239675885.1 NZ_CP070499:c4425030-4424683 [Natronosporangium hydrolyticum]
MRRGEVYLVDLEPAQGAEANKVRPAVVVSNDAANRSAEQTGRGVVTVVPVTSNTGRVYPFQVLLRAADSGLREDSKAQAE
QVRSVAVRRIRQRVGGLPAPVLAELDRALRLHLAL
MRRGEVYLVDLEPAQGAEANKVRPAVVVSNDAANRSAEQTGRGVVTVVPVTSNTGRVYPFQVLLRAADSGLREDSKAQAE
QVRSVAVRRIRQRVGGLPAPVLAELDRALRLHLAL
Download Length: 348 bp
>T194194 NZ_CP093386:2459480-2459764 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8525.21 Da Isoelectric Point: 4.1353
>AT194194 WP_239675886.1 NZ_CP070499:c4425253-4425017 [Natronosporangium hydrolyticum]
MKLSVSLPEADVAFLDDYATRAGGSSRSSVVQRAIRLLRTAELEEAYAHAYQEWEASEDAELWDRAAGDGDGYGDASR
MKLSVSLPEADVAFLDDYATRAGGSSRSSVVQRAIRLLRTAELEEAYAHAYQEWEASEDAELWDRAAGDGDGYGDASR
Download Length: 237 bp
>AT194194 NZ_CP093386:2459242-2459490 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA