Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3223954..3224591 Replicon chromosome
Accession NZ_CP070499
Organism Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQS43_RS14330 Protein ID WP_239674888.1
Coordinates 3224208..3224591 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQS43_RS14325 Protein ID WP_239674887.1
Coordinates 3223954..3224211 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQS43_RS14295 (JQS43_14225) 3219731..3220108 + 378 WP_239674881.1 VOC family protein -
JQS43_RS14300 (JQS43_14230) 3220156..3221661 - 1506 WP_239674882.1 class I SAM-dependent DNA methyltransferase -
JQS43_RS14305 (JQS43_14235) 3221836..3222261 - 426 WP_239674883.1 type II toxin-antitoxin system VapC family toxin -
JQS43_RS14310 (JQS43_14240) 3222258..3222497 - 240 WP_239674884.1 antitoxin -
JQS43_RS14315 (JQS43_14245) 3222816..3223025 - 210 WP_239674885.1 type II toxin-antitoxin system VapB family antitoxin -
JQS43_RS14320 (JQS43_14250) 3223311..3223742 - 432 WP_239674886.1 type II toxin-antitoxin system VapC family toxin -
JQS43_RS14325 (JQS43_14255) 3223954..3224211 + 258 WP_239674887.1 CopG family transcriptional regulator Antitoxin
JQS43_RS14330 (JQS43_14260) 3224208..3224591 + 384 WP_239674888.1 type II toxin-antitoxin system VapC family toxin Toxin
JQS43_RS14335 (JQS43_14265) 3224959..3225216 - 258 WP_239674889.1 hypothetical protein -
JQS43_RS14340 (JQS43_14270) 3225275..3225511 - 237 WP_239674890.1 hypothetical protein -
JQS43_RS14345 (JQS43_14275) 3225511..3225768 - 258 WP_239674891.1 hypothetical protein -
JQS43_RS14350 (JQS43_14280) 3225722..3226360 - 639 WP_239674892.1 ABC transporter substrate-binding protein -
JQS43_RS14355 (JQS43_14285) 3226519..3226983 - 465 WP_239674893.1 hypothetical protein -
JQS43_RS14360 (JQS43_14290) 3227129..3227761 - 633 WP_239674894.1 hypothetical protein -
JQS43_RS14365 (JQS43_14295) 3227976..3228164 - 189 WP_239674895.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14053.29 Da        Isoelectric Point: 9.9567

>T194193 WP_239674888.1 NZ_CP070499:3224208-3224591 [Natronosporangium hydrolyticum]
VILIDSDVLIAHLRGVEPARDWLRKARTTGPLAVSVVSIAELTGGMRSAERREVFALLGALRAEPVTELVARRAGEFMRQ
YRRSHNGIGIADYLIAATAELHGQQLATLNVRHFPMFADLRPPFEVP

Download         Length: 384 bp

>T194193 NZ_CP093386:2117534-2117637 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9352.44 Da        Isoelectric Point: 4.3952

>AT194193 WP_239674887.1 NZ_CP070499:3223954-3224211 [Natronosporangium hydrolyticum]
MTRTNIYLEERQTAILDRIAGEEGVSRAEVIRRLIDRALAGRDDDLTADLAAIDESFGALGELDVPARGASDREAHLSRM
WQVAA

Download         Length: 258 bp

>AT194193 NZ_CP093386:c2117639-2117494 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References