Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1808508..1809124 Replicon chromosome
Accession NZ_CP070499
Organism Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQS43_RS08200 Protein ID WP_239678458.1
Coordinates 1808732..1809124 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQS43_RS08195 Protein ID WP_239678457.1
Coordinates 1808508..1808735 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQS43_RS08165 (JQS43_08135) 1804275..1804907 + 633 WP_239678453.1 class I SAM-dependent methyltransferase -
JQS43_RS08170 (JQS43_08140) 1805006..1805662 - 657 WP_239678454.1 winged helix-turn-helix transcriptional regulator -
JQS43_RS08175 (JQS43_08145) 1805788..1806834 + 1047 WP_239678455.1 alpha/beta hydrolase -
JQS43_RS08180 (JQS43_08150) 1807321..1807920 + 600 Protein_1603 hypothetical protein -
JQS43_RS26040 (JQS43_08155) 1807956..1808408 + 453 WP_275581080.1 hypothetical protein -
JQS43_RS08195 (JQS43_08160) 1808508..1808735 + 228 WP_239678457.1 hypothetical protein Antitoxin
JQS43_RS08200 (JQS43_08165) 1808732..1809124 + 393 WP_239678458.1 PIN domain-containing protein Toxin
JQS43_RS08205 (JQS43_08170) 1809161..1809574 + 414 WP_239678459.1 Imm10 family immunity protein -
JQS43_RS08210 (JQS43_08175) 1809593..1810006 - 414 WP_239678460.1 PIN domain-containing protein -
JQS43_RS08215 (JQS43_08180) 1810010..1810222 - 213 WP_239678461.1 hypothetical protein -
JQS43_RS08220 (JQS43_08185) 1810372..1812693 - 2322 WP_239678462.1 hypothetical protein -
JQS43_RS08225 (JQS43_08190) 1812690..1813370 - 681 WP_239678463.1 ABC transporter ATP-binding protein -
JQS43_RS08230 (JQS43_08195) 1813414..1813935 - 522 WP_239678464.1 PadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14077.97 Da        Isoelectric Point: 6.8434

>T194191 WP_239678458.1 NZ_CP070499:1808732-1809124 [Natronosporangium hydrolyticum]
VTFLLDANVVVALCAADHVHHEVASAWFSQTQEPFATTPITQGSVLRFLLREGVDAANALEVMGSVTGHPRHEFWPGDLP
FTNETLRGVVGHRQVTDAYLANQARRRGGKVATLDKGLVALHADVATLVR

Download         Length: 393 bp

>T194191 NZ_CP093386:850390-850788 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8327.43 Da        Isoelectric Point: 4.7824

>AT194191 WP_239678457.1 NZ_CP070499:1808508-1808735 [Natronosporangium hydrolyticum]
MRTTVDLPDDLHQMVTAVARDEGKSMSRAIADLLRRQLAPPAGPPMSTDERTGLRVVRLGRPITSEDVRSLEDEE

Download         Length: 228 bp

>AT194191 NZ_CP093386:850163-850390 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References