Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 145488..146182 Replicon chromosome
Accession NZ_CP070499
Organism Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQS43_RS00695 Protein ID WP_239677112.1
Coordinates 145748..146182 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQS43_RS00690 Protein ID WP_239677111.1
Coordinates 145488..145751 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQS43_RS00675 (JQS43_00670) 141739..142212 + 474 WP_239677108.1 Lrp/AsnC family transcriptional regulator -
JQS43_RS00680 (JQS43_00675) 142255..143646 + 1392 WP_239677109.1 PQQ-binding-like beta-propeller repeat protein -
JQS43_RS00685 (JQS43_00680) 143682..145343 + 1662 WP_239677110.1 fumarate hydratase -
JQS43_RS00690 (JQS43_00685) 145488..145751 + 264 WP_239677111.1 hypothetical protein Antitoxin
JQS43_RS00695 (JQS43_00690) 145748..146182 + 435 WP_239677112.1 type II toxin-antitoxin system VapC family toxin Toxin
JQS43_RS00700 (JQS43_00695) 146190..146960 + 771 WP_239677113.1 DUF4184 family protein -
JQS43_RS00705 (JQS43_00700) 146965..148356 + 1392 WP_239677114.1 class II fumarate hydratase -
JQS43_RS00710 (JQS43_00705) 148373..149053 + 681 WP_239677115.1 HAD family hydrolase -
JQS43_RS00715 (JQS43_00710) 149118..150374 + 1257 WP_239677116.1 serine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15708.99 Da        Isoelectric Point: 4.7778

>T194187 WP_239677112.1 NZ_CP070499:145748-146182 [Natronosporangium hydrolyticum]
VIIVDVNLLLYAVITGFAEHQRARAWFEATLNSPTQVVLTAPAVFGFLRIATSPRVMVSPLPVADAVGYIQSWLERPNVE
FRSPGPRHLAIAFDLLARIGTAGNLTTDVQLAAYAIEFDAEICSNDADFGRFPDVRWANPLSPG

Download         Length: 435 bp

>T194187 NZ_CP093386:206681-207166 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9966.21 Da        Isoelectric Point: 5.5743

>AT194187 WP_239677111.1 NZ_CP070499:145488-145751 [Natronosporangium hydrolyticum]
MRTTLTLDRDVVQLLEDAIHRERRPMKQVVNDALRQALGPTGTADAEPYHLQPHESALRPGLDLTGFNRLADELEDERIL
ERVRHTS

Download         Length: 264 bp

>AT194187 NZ_CP093386:206406-206693 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References