Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4894873..4895312 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JWZ98_RS22485 Protein ID WP_084254078.1
Coordinates 4894873..4895100 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JWZ98_RS22490 Protein ID WP_205452338.1
Coordinates 4895103..4895312 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS22460 4890100..4890570 - 471 WP_205452324.1 hypothetical protein -
JWZ98_RS22465 4890717..4891523 + 807 WP_205452330.1 helix-turn-helix domain-containing protein -
JWZ98_RS22470 4891525..4892685 - 1161 WP_205452332.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
JWZ98_RS22475 4892757..4893239 + 483 WP_205452335.1 MarR family transcriptional regulator -
JWZ98_RS22480 4893263..4894489 + 1227 WP_205452337.1 RNA polymerase sigma factor -
JWZ98_RS22485 4894873..4895100 - 228 WP_084254078.1 type II toxin-antitoxin system HicA family toxin Toxin
JWZ98_RS22490 4895103..4895312 - 210 WP_205452338.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JWZ98_RS22495 4895372..4895683 - 312 WP_205452339.1 hypothetical protein -
JWZ98_RS22500 4895687..4896442 - 756 WP_205452340.1 DUF3800 domain-containing protein -
JWZ98_RS22505 4896790..4896954 - 165 WP_205452342.1 hypothetical protein -
JWZ98_RS22510 4896951..4897220 - 270 WP_205452343.1 hypothetical protein -
JWZ98_RS22515 4897267..4897551 - 285 WP_205452344.1 hypothetical protein -
JWZ98_RS22520 4897860..4898252 + 393 WP_205452345.1 YciI family protein -
JWZ98_RS22525 4898374..4898859 + 486 WP_205452347.1 VOC family protein -
JWZ98_RS22530 4898902..4899309 + 408 WP_205452348.1 VOC family protein -
JWZ98_RS22535 4899321..4899677 + 357 WP_205452349.1 YciI family protein -
JWZ98_RS22540 4899703..4900230 + 528 WP_205452350.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8458.93 Da        Isoelectric Point: 10.3070

>T194186 WP_084254078.1 NZ_CP070494:c4895100-4894873 [Methylomonas sp. EFPC1]
MGNVPVLKPREVVALLEILGFTEIRQRGSHKQFRHPDGRCTTVPFHAGRDISPILLRQIAKDIGLTVEELLKFQA

Download         Length: 228 bp

>T194186 NZ_CP093381:c498124-497534 [Rhodococcus opacus]
GTGAAACGACTCGACCTGGTGGTCGGTTGCAACGGCGCCGGCAAGTCCACCTTCGTGGCCTTCACCCTCGCTCCACTGCT
TCCGGCCAGCCCGTTCGTCAATGCCGACGAGATCGCCACACAACGATGGCCGGCAGATCCGGCCGCACACTCCTATGAGG
CCGCGGAGATCGCCGCGAAGACCCGGGCACACCTGCTGACCCTGGGGAAATCGTTCATCGCCGAGACGGTGTTCTCCCAT
CCGTCGAAGCTGGAGCTGATCGACGAAGCGCGCACACACGACTACACCGTCGTCTTACATGTGGTGATGATTCCCGAGGA
GCTAGCGGTCCAGCGTGTGCGCTACCGGGTGCGAGCCGGCGGACACGATGTGCCCGAAGACAAGATCCGCCAGCGATACC
ACAGATTGTGGGGTCTCGTCGCTCAGGCGTTCCCGCGGTGTGATCACGTAACCGTGTACGACAACAGCGCGAGCACCGGC
CCGCGCATCGTCGCCCAGTTCACCGACGGACACCTCGTCGGCGAAGCCACCTGGCCCGCATGGACACCCGCAGAACTGAC
CTCGCACACCAGCCGGGGCGAGCAACCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7608.63 Da        Isoelectric Point: 3.9323

>AT194186 WP_205452338.1 NZ_CP070494:c4895312-4895103 [Methylomonas sp. EFPC1]
MKIYTAIIEKCHDTGLYVGFIPGFTGAHSQADSLDELNQNLREVIEMLLEDGEPILEAEFIGTQNVVVA

Download         Length: 210 bp

>AT194186 NZ_CP093381:c498504-498121 [Rhodococcus opacus]
ATGCACAGCACAGGAGACAAGGTCACCCGCCTGGCAGCGGACCTGGTGGCCAGCGCCATGGCCGAGGGAGAACGGCAACA
CCGCACCGGACGCCAGCAACTCGAACACTGGGCCCGGGTGGGCCGTGCGGTCTCGAGCCGGCAGACCGCGGCCCGGCGCC
GAGTAGAAGACGCCCTCGCCGGCCGGTTGCCGATCGGTGAACTCGGACCCGAAGAAGGCACAGTATTCAACGCCGAGATC
AACGCGGCGATCGAGGAACAACTGGCCACCACCGACTACGGCGCCGCACTCGCGGCCCAGGGAATCACCACGGTCGCGCT
GTCCGAGGACGGTCAGATCATCGAGTACCGCCCCGACGGCACGCGCACAGTCCTGCCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References