Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 4163737..4164318 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JWZ98_RS19080 Protein ID WP_205451370.1
Coordinates 4164025..4164318 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag JWZ98_RS19075 Protein ID WP_205451369.1
Coordinates 4163737..4164021 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS19060 4159530..4161941 - 2412 WP_205451366.1 carbamoyltransferase HypF -
JWZ98_RS19065 4161941..4162978 - 1038 WP_205451367.1 hydrogenase expression/formation protein HypE -
JWZ98_RS19070 4163071..4163610 - 540 WP_205451368.1 hypothetical protein -
JWZ98_RS19075 4163737..4164021 - 285 WP_205451369.1 putative addiction module antidote protein Antitoxin
JWZ98_RS19080 4164025..4164318 - 294 WP_205451370.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JWZ98_RS19085 4164527..4164781 + 255 WP_101054273.1 prevent-host-death protein -
JWZ98_RS19090 4164781..4165056 + 276 WP_101054276.1 plasmid stabilization protein -
JWZ98_RS19095 4165291..4165548 + 258 WP_101054279.1 hypothetical protein -
JWZ98_RS19100 4165613..4166722 - 1110 WP_101054282.1 hydrogenase formation protein HypD -
JWZ98_RS19105 4166719..4166946 - 228 WP_101054284.1 HypC/HybG/HupF family hydrogenase formation chaperone -
JWZ98_RS19110 4167029..4167322 - 294 WP_101054287.1 type II toxin-antitoxin system RelE/ParE family toxin -
JWZ98_RS19115 4167319..4167531 - 213 WP_101054291.1 addiction module protein -
JWZ98_RS19120 4167588..4168415 - 828 WP_205451371.1 hydrogenase nickel incorporation protein HypB -
JWZ98_RS19125 4168415..4168756 - 342 WP_205451372.1 hydrogenase maturation nickel metallochaperone HypA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-95)

Antitoxin

Uncharacterized protein HI1420

(8-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10814.52 Da        Isoelectric Point: 9.9662

>T194185 WP_205451370.1 NZ_CP070494:c4164318-4164025 [Methylomonas sp. EFPC1]
MNYVVQQTESFAKWLASLKDLRAKTAIYRRIDRAQAGNLGDTKAVGEGVCEMRIDLGAGYRVYYTIRNGMMIILLAGGDK
STQQSDIQRAIKLAKEV

Download         Length: 294 bp

>T194185 NZ_CP093380:c1330395-1330114 [Rhodococcus opacus]
GTGATCGAGTCGTTCGCCGACAAAGAGACCGAGCGGGTCTTTCACCGACAGTTCTCGAAGAAGCTCCCGCAGGACATTCA
GCGGATCGCGCGCCGGCGCCTCCTGTTGATCGAGGCTGCCACCGACGTCAACGACCTGAGGGTGCCCCCAGGCAACCGCC
TGGAGAAGCTCTCCGGGGACCGGTTGGGCCAGTACAGCGTTCGGATCAATGATCAGTACCGCATCTGTTTCATCTGGCGC
GCCACCGCCGCATACGACGTGGAGATCACCGACTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10249.89 Da        Isoelectric Point: 4.6412

>AT194185 WP_205451369.1 NZ_CP070494:c4164021-4163737 [Methylomonas sp. EFPC1]
MSEQLLPFDMTTLLDSDEAISEYLNQVLEEGDSDELIRALGYIAKAKGMAMIAKESGLGRESLYKALAPGAKPRFDTVLK
VIRALGVKLHAEPV

Download         Length: 285 bp

>AT194185 NZ_CP093380:c1330055-1329762 [Rhodococcus opacus]
ATGACTACAGACCTGAGCCCAATTCACCCCGGCGAGATCCTCCGCGAGGACTTCCTCGAGCCGTTCGGCATCACGCAGAA
CCGCCTAGCCACGATCATCGGTGTTCCGCCCCGACGGATCAACGAGATCGTGCTCGGCAAGCGGTCGATCACCGCAGACA
CCGCGTTGCGGCTGGCCAAGGCGTTCGGCAACAGTGCGCAGTTCTGGCTCAATATCCAGGACCGCTACGAGCTCGACCTT
GCGGCCGACAAGATAGGCGACGCCCTCGCCAAGATCACGCGTCTCTCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References