Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 4105612..4106144 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JWZ98_RS18790 Protein ID WP_205451339.1
Coordinates 4105612..4105935 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JWZ98_RS18795 Protein ID WP_205451340.1
Coordinates 4105932..4106144 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS18775 4100738..4102345 + 1608 WP_205451338.1 nitroreductase family protein -
JWZ98_RS18780 4102456..4102851 + 396 WP_033159164.1 hypothetical protein -
JWZ98_RS18785 4102960..4105442 - 2483 Protein_3704 DEAD/DEAH box helicase family protein -
JWZ98_RS18790 4105612..4105935 - 324 WP_205451339.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JWZ98_RS18795 4105932..4106144 - 213 WP_205451340.1 DUF3018 family protein Antitoxin
JWZ98_RS18800 4106219..4106782 - 564 WP_205454495.1 hypothetical protein -
JWZ98_RS18805 4106680..4107417 - 738 WP_205451341.1 restriction endonuclease subunit S -
JWZ98_RS18810 4107589..4107987 - 399 WP_205451342.1 GIY-YIG nuclease family protein -
JWZ98_RS18815 4107984..4109438 - 1455 Protein_3710 N-6 DNA methylase -
JWZ98_RS18820 4109494..4110834 - 1341 WP_205451343.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

Antitoxin MazE-like

(7-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11429.28 Da        Isoelectric Point: 8.9153

>T194184 WP_205451339.1 NZ_CP070494:c4105935-4105612 [Methylomonas sp. EFPC1]
VRRGDLVTVALQGDLGKPRPALLIQSDLFDAHPSVTILPITSELRDAPLFRIAVAANERTGLSLASQIMVDKPQSVARNK
IGGVIGRIDDETLLSVNRALAVFLGFA

Download         Length: 324 bp

>T194184 NZ_CP093379:c442964-442785 [Ignatzschineria rhizosphaerae]
ATGAATAGCAAAGATTTAATAAAGATGATTGAAAAAGATGGATGGTATCTAGTAGCAACAAGAGGTTCACATCATCAATT
CAAACATCCGACCAAATCGGGAAGAGTCACAATCCCTCACCCCAAGAAAGACCTACCGAAAGGAACAGTCAAAAACATAA
TGAAGCAAGCGGGCATCTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8128.07 Da        Isoelectric Point: 6.4561

>AT194184 WP_205451340.1 NZ_CP070494:c4106144-4105932 [Methylomonas sp. EFPC1]
MRTVTSARVQKHRIALREAGLRPLQIWVPDTRREGFAEECRRQSLSIQNDAAEQDALNWLETVADHDGWQ

Download         Length: 213 bp

>AT194184 NZ_CP093379:c442740-442336 [Ignatzschineria rhizosphaerae]
ATGTTATTTCACTTAGTGATTCATAAAGATGAAGATAGTACCTATGGAGTAACTATCCCATCCTTAGAGGGGGCTTTTTC
TCATGGTGACACATTAGAAGAAGCTGTATTAAACTCAAAAGAAGCAATCCAATTCCATCTTGAAGGAATTCTTGAAGATG
GGATCGAGCCTGATTTTAAACATCTCACATTAGATGAGATCAAGACTAATCCTGACTATCAAGGAGCTGATCTGATCTCC
GTTGATATTGATACATCTGCTTATACACTTAAACCTGAACGATTTAATGTTAGCTGGCCAAGGTATCTCATCAAAGAAGT
AGACCAATATACAACTCAGCATCCTGATACTCGCTCAAGCTTTCTTGCTAAAGCAGCTAAAAAATATATTGAGCAGAATC
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References