Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4021739..4022283 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JWZ98_RS18400 Protein ID WP_205454490.1
Coordinates 4021739..4022038 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag JWZ98_RS18405 Protein ID WP_205454491.1
Coordinates 4022035..4022283 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS18370 4017298..4017990 + 693 WP_205451290.1 leucyl/phenylalanyl-tRNA--protein transferase -
JWZ98_RS18375 4017987..4018709 + 723 WP_205451291.1 arginyltransferase -
JWZ98_RS18380 4018713..4019279 + 567 WP_033159245.1 elongation factor P-like protein YeiP -
JWZ98_RS18385 4019276..4019419 - 144 WP_205451292.1 hypothetical protein -
JWZ98_RS18390 4019638..4020657 - 1020 WP_205451293.1 restriction endonuclease -
JWZ98_RS18395 4020742..4021317 - 576 WP_205451294.1 hypothetical protein -
JWZ98_RS18400 4021739..4022038 - 300 WP_205454490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JWZ98_RS18405 4022035..4022283 - 249 WP_205454491.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JWZ98_RS18410 4022737..4023462 + 726 WP_205451295.1 ATP-binding cassette domain-containing protein -
JWZ98_RS18415 4023459..4024871 + 1413 WP_205451296.1 DUF3526 domain-containing protein -
JWZ98_RS18420 4024868..4026250 + 1383 WP_205451297.1 DUF3526 domain-containing protein -
JWZ98_RS18425 4026313..4026522 - 210 WP_033159049.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11696.50 Da        Isoelectric Point: 9.8132

>T194183 WP_205454490.1 NZ_CP070494:c4022038-4021739 [Methylomonas sp. EFPC1]
IMATYRITPRAFSDLKSIGRYTTKKWGKPQRNRYLADLDKRFNWLAKHPHLGKHRTDIAEGYYCFPLGSHLIFYMLNPFG
IDIIGIPHQAMDFEAYFDQ

Download         Length: 300 bp

>T194183 NZ_CP093376:2691534-2691752 [Cronobacter sakazakii]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTGAGACGTTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAACGAACTGGCGGTATTTTATTCAGCGGCGGATCATCGTCTGGCTGAAC
TGACGATGAATAAGCTCTACGATAAAATTCCGACCGCCGTGTGGAAGTTCGTTCGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9001.02 Da        Isoelectric Point: 4.8377

>AT194183 WP_205454491.1 NZ_CP070494:c4022283-4022035 [Methylomonas sp. EFPC1]
MATTSLSLGEHWEVFIRSEIASGRYGSASEVVRDALRELEERKHKLAALRAHLAEGAAQASRGEFVQDYTVAAIIQELDS
EA

Download         Length: 249 bp

>AT194183 NZ_CP093376:2691133-2691507 [Cronobacter sakazakii]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTTGC
CACGCTCGGTGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCTGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGCCTGAATTATAAAATTAAGCATGAAGATGACGCAGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCAAAGAAAACCCTGTAAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References