Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 3903836..3904478 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name vapC Uniprot ID A0A2N0V2E8
Locus tag JWZ98_RS17805 Protein ID WP_033158368.1
Coordinates 3904059..3904478 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2N0V2K6
Locus tag JWZ98_RS17800 Protein ID WP_033158369.1
Coordinates 3903836..3904072 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS17790 3899802..3902273 + 2472 WP_205454485.1 TonB-dependent receptor -
JWZ98_RS17795 3902527..3903768 + 1242 WP_101054631.1 amidohydrolase family protein -
JWZ98_RS17800 3903836..3904072 + 237 WP_033158369.1 DNA-binding protein Antitoxin
JWZ98_RS17805 3904059..3904478 + 420 WP_033158368.1 type II toxin-antitoxin system VapC family toxin Toxin
JWZ98_RS17810 3904475..3905392 - 918 WP_205451235.1 class I SAM-dependent methyltransferase -
JWZ98_RS17815 3905514..3906302 - 789 WP_205451236.1 4,5-DOPA dioxygenase extradiol -
JWZ98_RS17820 3906337..3907218 - 882 WP_205451237.1 pirin family protein -
JWZ98_RS17825 3907246..3907845 - 600 WP_205451238.1 NAD(P)H-dependent oxidoreductase -
JWZ98_RS17830 3907948..3908847 + 900 WP_205451239.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15683.02 Da        Isoelectric Point: 7.4646

>T194182 WP_033158368.1 NZ_CP070494:3904059-3904478 [Methylomonas sp. EFPC1]
MYLIDTNVISEIRKGSKTNPGVNQFFAGVAQNDHKLYISVVTVGELRRGVDLIYHRGDFSQGKLLENWLNQLMQEYRHHV
LPIDNEIALVWGKMRVPNPQHPLDKLIAATALIYDLTVVTRNVGDFAGTGIRVLNPFAD

Download         Length: 420 bp

>T194182 NZ_CP093376:c1775335-1775057 [Cronobacter sakazakii]
ATGATCAGAAGCTTCAGGCATAAAGGCCTGCAACGCTATTTCGAAACGGGTTCCACCGCAGGCATTCATGCCCGCCATGC
CAGAAAGATTTCTCTGCGGCTGGCGGTGCTGAATCAGGCGATAAGCCCCGCTGACGTCGACTTACCGGGCTTTTTCCTGC
ATCCCCTGACGGGGGATCGTAAAGGTATATGGGCTGTGACCGTCAGCGGAAACTGGCGCATCACGTTTGAGTTTCGGGAT
GGCGATGTCTTTATCGTCAATTATGAGGATTACCACTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8531.62 Da        Isoelectric Point: 5.0484

>AT194182 WP_033158369.1 NZ_CP070494:3903836-3904072 [Methylomonas sp. EFPC1]
MPSLVVRNLDESLVKALKARAAAHHRSTEAEHRAILAEVLTGPQRKSFTEVLAAMPNVGSDTDFLRVDTESDLADVFD

Download         Length: 237 bp

>AT194182 NZ_CP093376:c1775057-1774770 [Cronobacter sakazakii]
ATGGCAACGATGTTTAACCCACCGCACCCGGGCAGGCTGGTGCAGGAGTCAATGGAAGCGCTCGGCCTCAGCGCCCGTGC
GCTGGCCAAAGCGCTGGACGTCGCGCCGTCGACGGTGCAGCGGCTGCTGGTCGGCAAATCTGACGTCTCCCCGGAAATGG
CGCTGCGTCTCTCGGCAGTCCTTGGCAGCTCGCCGCATGTCTGGCTGGGTATGCAAAACGAATACGATCTCTTTCAGGCG
CGCCAGTCTGTTGATTTCTCGCACCTGCAACGGTTGCAGAGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N0V2E8

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V2K6

References