Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3646919..3647496 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JWZ98_RS16740 Protein ID WP_171696149.1
Coordinates 3646919..3647104 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N0V2Y5
Locus tag JWZ98_RS16745 Protein ID WP_033155605.1
Coordinates 3647101..3647496 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS16730 3642383..3643837 - 1455 Protein_3302 SAM-dependent DNA methyltransferase -
JWZ98_RS16735 3643940..3646303 - 2364 WP_205451075.1 DEAD/DEAH box helicase family protein -
JWZ98_RS16740 3646919..3647104 + 186 WP_171696149.1 type II toxin-antitoxin system HicA family toxin Toxin
JWZ98_RS16745 3647101..3647496 + 396 WP_033155605.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JWZ98_RS16750 3647500..3648242 - 743 Protein_3306 site-specific integrase -
JWZ98_RS16760 3648555..3648956 - 402 WP_171696150.1 preprotein translocase subunit SecG -
JWZ98_RS16765 3648978..3649724 - 747 WP_205451076.1 triose-phosphate isomerase -
JWZ98_RS16770 3649779..3651119 - 1341 WP_033155614.1 phosphoglucosamine mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6842.07 Da        Isoelectric Point: 10.7918

>T194181 WP_171696149.1 NZ_CP070494:3646919-3647104 [Methylomonas sp. EFPC1]
MNSRQLIKLLEDDGWTLRSVKGSHHIFVHPVKPGHLTVPHPKSDLGKGLVNKLLKQAELKV

Download         Length: 186 bp

>T194181 NZ_CP093376:1363638-1363741 [Cronobacter sakazakii]
GGCAAGGCGACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14369.35 Da        Isoelectric Point: 4.3410

>AT194181 WP_033155605.1 NZ_CP070494:3647101-3647496 [Methylomonas sp. EFPC1]
MRFFVAIEPGDEDHAFGVVVPDLPGCFSAGDTLDEAFENAKEAIDLWCETVIEDGAMIPPGKTLAEHQANPEFAGWVWSI
VEVPVERYLGPAEKINITLPKLLLTRIDEYAKAHGATRSGFLAQAARQAMR

Download         Length: 396 bp

>AT194181 NZ_CP093376:c1363744-1363576 [Cronobacter sakazakii]
GATAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAGTCGCCTTGCCTTTTAAGAATAGATGACGACACCAGCTTTTCCAGTTTGCGGCTAAAGTCGCAG
CAAAAAGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V2Y5

References