Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2503808..2505300 Replicon chromosome
Accession NZ_CP070494
Organism Methylomonas sp. EFPC1

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag JWZ98_RS11810 Protein ID WP_205450214.1
Coordinates 2503808..2505070 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag JWZ98_RS11815 Protein ID WP_205450215.1
Coordinates 2505067..2505300 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWZ98_RS11790 2499738..2500331 - 594 WP_033156245.1 SRPBCC family protein -
JWZ98_RS11795 2500459..2501877 + 1419 WP_101052323.1 exodeoxyribonuclease I -
JWZ98_RS11800 2502003..2503184 + 1182 WP_205450213.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
JWZ98_RS11810 2503808..2505070 - 1263 WP_205450214.1 HipA domain-containing protein Toxin
JWZ98_RS11815 2505067..2505300 - 234 WP_205450215.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
JWZ98_RS11820 2505522..2506562 - 1041 WP_205450216.1 IS481 family transposase -
JWZ98_RS11825 2506893..2507117 - 225 WP_205450217.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2505522..2506562 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 46402.42 Da        Isoelectric Point: 7.0914

>T194180 WP_205450214.1 NZ_CP070494:c2505070-2503808 [Methylomonas sp. EFPC1]
MSYLLAVYLFDRRVGDLALVEGRLQFCYCADWLQHADAVPLSCSLPLQVEVFNDQQTRPFFAGLLPEGKLRQLIARQFQV
SKQNDFALLDHIGGECAGAVSLLPPDRLPAVSEPANEIDWLSDSDVVALLDELPQRPMLAGRDGLRLSLAGAQDKLPVVF
DGQRIGLPRNGTPSSHILKPAIAAVEDSVINEGFCLALAGAMQFQTAQSRICAIRDRSFLLVERYDRTQTAIGQCVRLHQ
EDFCQALGVVPELKYQNEGGPGLERCFDLVRRVTRPSATQVLRLLDAVIFNALIGNHDAHAKNFSILYADKGAVLAPLYD
VLSTAVYPSLTPKMAMQLGGKYKFSEVQARHWDRFAQAAGLSVAQTRKRILGLCQRLPVVARRLQTSADHEFAGNPVIEQ
LVQLIEQRAALTVRRFAGFD

Download         Length: 1263 bp

>T194180 NZ_CP070494:c2505070-2503808 [Methylomonas sp. EFPC1]
ATGAGCTATTTGCTTGCTGTCTATTTATTTGATCGTCGAGTAGGGGATTTGGCCCTGGTTGAAGGCAGACTGCAATTTTG
CTACTGCGCCGACTGGCTGCAACATGCCGACGCCGTCCCGCTGTCCTGCTCGTTACCGTTGCAAGTAGAGGTTTTCAACG
ACCAACAGACGCGGCCTTTCTTTGCTGGATTGTTACCGGAAGGCAAATTACGCCAACTGATTGCTCGCCAGTTTCAGGTC
TCGAAGCAGAACGACTTTGCCTTGCTCGATCATATCGGCGGCGAATGCGCTGGTGCGGTTTCGCTATTGCCGCCAGACCG
ATTACCCGCTGTATCTGAACCAGCGAACGAGATCGACTGGTTATCCGACTCTGACGTAGTGGCCTTGCTGGATGAATTGC
CACAGCGGCCGATGCTGGCTGGTCGAGATGGCTTGCGCCTGTCCTTGGCGGGCGCTCAGGATAAGTTGCCGGTGGTATTT
GATGGTCAACGAATCGGTCTGCCCCGCAATGGCACGCCCAGTAGTCATATTCTCAAACCGGCCATCGCTGCCGTTGAAGA
CAGTGTAATCAACGAAGGTTTCTGTCTGGCATTGGCAGGTGCAATGCAATTCCAGACCGCACAGTCGAGGATTTGTGCCA
TTCGCGACCGCTCATTTTTGCTGGTTGAGCGTTATGACAGAACTCAAACTGCAATTGGCCAATGCGTGCGTCTGCATCAG
GAAGATTTCTGCCAGGCACTAGGCGTGGTACCGGAACTGAAATATCAGAACGAGGGTGGGCCGGGTTTGGAACGGTGCTT
CGATTTGGTCCGCCGCGTGACCCGACCGAGTGCGACGCAGGTGTTGCGACTGCTGGATGCGGTCATTTTCAATGCCTTGA
TTGGCAACCACGACGCCCATGCCAAGAACTTTTCTATCTTGTATGCCGACAAGGGTGCCGTTCTGGCGCCACTTTATGAC
GTCCTGTCAACCGCCGTTTATCCCAGTCTGACGCCCAAGATGGCAATGCAGTTGGGTGGCAAATATAAATTTAGCGAAGT
GCAGGCAAGACACTGGGACCGCTTTGCCCAAGCGGCGGGCTTGTCGGTAGCGCAAACCCGAAAACGCATTCTTGGTTTGT
GCCAACGGCTACCGGTGGTTGCTCGCAGGTTGCAGACATCGGCGGATCATGAATTTGCTGGAAACCCAGTGATTGAACAA
CTCGTACAGCTGATCGAGCAACGCGCGGCGCTGACGGTCAGGCGGTTCGCCGGGTTTGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8260.68 Da        Isoelectric Point: 4.6082

>AT194180 WP_205450215.1 NZ_CP070494:c2505300-2505067 [Methylomonas sp. EFPC1]
MINIQSTQQLGLALRSARKQLELTQSELALAAGVGVRFIVDLEAGKPTVRLETVMRVIEALGGQVMLDGLPDMTEAP

Download         Length: 234 bp

>AT194180 NZ_CP070494:c2505300-2505067 [Methylomonas sp. EFPC1]
ATGATCAACATCCAATCTACACAACAACTTGGCCTAGCGCTACGCTCTGCCCGCAAACAGCTCGAATTAACTCAATCCGA
ATTGGCGTTGGCGGCAGGTGTTGGCGTTCGTTTTATCGTCGACCTCGAAGCAGGCAAGCCGACCGTGCGTCTGGAAACGG
TGATGCGCGTGATTGAAGCACTGGGTGGGCAGGTCATGCTCGATGGCCTGCCGGACATGACCGAAGCACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References