Detailed information of TA system TA194179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 1629355..1629857
• Replicon: chromosome
• Accession: NZ_CP070494
• Organism: Methylomonas sp. EFPC1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JWZ98_RS07705
• Protein ID: WP_205453849.1
• Coordinates: 1629355..1629618 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JWZ98_RS07710
• Protein ID: WP_205453850.1
• Coordinates: 1629615..1629857 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWZ98_RS07695	1626330..1627511	+	1182	WP_205453847.1	aminoacetone oxidase family FAD-binding enzyme	-
JWZ98_RS07700	1628071..1629180	+	1110	WP_205453848.1	hypothetical protein	-
JWZ98_RS07705	1629355..1629618	-	264	WP_205453849.1	Txe/YoeB family addiction module toxin	Toxin
JWZ98_RS07710	1629615..1629857	-	243	WP_205453850.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JWZ98_RS07715	1630037..1630582	-	546	WP_205453851.1	flavodoxin	-
JWZ98_RS07720	1631011..1632318	+	1308	WP_033157413.1	citrate synthase	-
JWZ98_RS07725	1632322..1632513	+	192	WP_205453852.1	DUF1674 domain-containing protein	-
JWZ98_RS07730	1632552..1632923	+	372	WP_205453853.1	succinate dehydrogenase, cytochrome b556 subunit	-
JWZ98_RS07735	1632937..1633317	+	381	WP_205453854.1	succinate dehydrogenase, hydrophobic membrane anchor protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10197.81 Da
• Isoelectric Point: 9.9111

>T194179 WP_205453849.1 NZ_CP070494:c1629618-1629355 [Methylomonas sp. EFPC1]
VSWEIIYTNQAQKDAKKLATAELKGKALQLIEILKNDPFQNPLPYEKLIGDLAGAYSRRINIQHRLIYQVLSNEKQVKVF
RLWSHYE

Nucleotide

• Length: 264 bp

>T194179 NZ_CP093376:1028677-1029024 [Cronobacter sakazakii]
ATGTGGACTATTTACCTTACTCACGAGTTTGAGTGCTGGCTCGCGAGACAGCCGCAGCCGTTGCAGGAAGATGTGCTGGC
CGCGCTGGGGCTTTTGAAAATCAAAGGTCCGCACCTCGGGCGTCCGTATGCCGATACGCTCAAAGGCTCGCGTCACGCGG
GTATGAAGGAATTACGGGTTCAGCACGCCGGGCGGCCCATACGCGCCTTTTACGCTTTTGATCCGCACCGTTATGCGATT
GTGCTGTGCGCGGCACAGAAAAAGGGGGATGAAAAGCGGTTTTACCGGGTCATGCTGCGCGTCGCTGACAAACTGTTTAG
CCACTATCTGAACCACCGGGAGGTATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8797.90 Da
• Isoelectric Point: 4.1947

>AT194179 WP_205453850.1 NZ_CP070494:c1629857-1629615 [Methylomonas sp. EFPC1]
MQTLTASEARANLYRLIDQTAESHQPIAITGKRANAVLLSADDWSAIQETLYLLSVPGMRESILEGMATSADECSKELDW

Nucleotide

• Length: 243 bp

>AT194179 NZ_CP093376:1029025-1029324 [Cronobacter sakazakii]
ATGAAGACGTTTGATGAAGTGCTGGCGGCGCAGACCCCGGAGGCCCGCGCGCGTATCGAAGAGAAAACGGCGCAGCTGCT
GCTGGAAACCCATCTGTATGCGCTGCGCGAGGCGCTCAGCGTGTCGCAAACCGAGATGGCGCGCCAGATGGGTATCGCCC
AGCCGTCGGTCGCGGCTATCGAACAGCGCGGCAACGAGATGAAAATCTCAACGCTTAAGCGCTATGTCGAAGCCCTGGGC
GGCACGGTGCGACTGGATGTCGAGCTGCCGGACGGCCAACGTTTCGGTTTTACGCTCTGA